Yucheng Wu, Jie Qiu, Xiang Sha, Benbingdi Gong, Jian Wang, Wei Yuan, Jie Lin, Lichun Wang, Qingqing Zhang
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引用次数: 0
Abstract
Background: Management strategies for stable angina include pharmacotherapy, revascularization, and exercise-based cardiac rehabilitation (CR). The optimal treatment for stable angina patients with severe coronary artery stenosis remains unclear. This study aimed to compare interventional therapy with exercise rehabilitation in this population.
Methods: Fifty stable angina patients with severe coronary stenosis who underwent stent implantation were included in the optimal medical therapy (OMT) plus percutaneous coronary intervention (PCI) group, and 50 patients who did not undergo interventional treatment were included in OMT plus CR group receiving exercise rehabilitation guidance for one year. Cardiovascular composite endpoint events, cardiopulmonary fitness, and quality of life scale scores were assessed after one year.
Results: No significant difference in incidence of cardiovascular composite endpoint events was observed between OMT plus PCI group with OMT plus CR group (20.0% vs 14.6%) after one year. Cardiopulmonary fitness represented as peak VO2 (19.2±3.5 vs 17.6±3.2 mL/kg/min), peak load (120±19 vs 108±20 W), and AT (13.5±1.5 vs 12.1±1.3 mL/kg/min) were significantly higher in the rehabilitation group than the intervention group after one year. Both groups showed improvement in their quality of life, but the rehabilitation group improved in more scales.
Conclusion: Interventional therapy did not reduce cardiovascular events compared to exercise-based rehabilitation in stable angina patients with severe coronary artery stenosis, but the rehabilitation can improve cardiovascular fitness and quality of life more.
背景：稳定型心绞痛的治疗策略包括药物治疗、血管重建和以运动为基础的心脏康复（CR）。对于冠状动脉严重狭窄的稳定型心绞痛患者，最佳治疗方法仍不明确。本研究旨在比较介入疗法和运动康复疗法在这一人群中的应用：50名接受了支架植入术的严重冠状动脉狭窄的稳定型心绞痛患者被纳入最佳药物治疗（OMT）加经皮冠状动脉介入治疗（PCI）组，50名未接受介入治疗的患者被纳入OMT加CR组，接受为期一年的运动康复指导。一年后对心血管综合终点事件、心肺功能和生活质量量表评分进行评估：结果：一年后，OMT+PCI组与OMT+CR组的心血管综合终点事件发生率无明显差异（20.0% vs 14.6%）。一年后，康复组的心肺功能峰值VO2（19.2±3.5 vs 17.6±3.2 mL/kg/min）、峰值负荷（120±19 vs 108±20 W）和AT（13.5±1.5 vs 12.1±1.3 mL/kg/min）显著高于干预组。两组患者的生活质量均有所改善，但康复组在更多量表上有所改善：结论：对于冠状动脉严重狭窄的稳定型心绞痛患者，介入治疗与运动康复治疗相比并不能减少心血管事件的发生，但康复治疗更能改善心血管健康状况和生活质量。
期刊介绍：
Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.
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