Prevalence and correlations of schistosomiasis mansoni and schistosomiasis haematobium among humans and intermediate snail hosts: a systematic review and meta-analysis.

IF 8.1 1区 医学
Xin-Yao Wang, Qin Li, Yin-Long Li, Su-Ying Guo, Shi-Zhu Li, Xiao-Nong Zhou, Jia-Gang Guo, Robert Bergquist, Saleh Juma, Jian-Feng Zhang, Kun Yang, Jing Xu
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引用次数: 0

Abstract

Background: The control of schistosomiasis is particularly difficult in sub-Saharan Africa, which currently harbours 95% of this disease. The target population for preventive chemotherapy (PC) is expanded to all age group at risk of infection, thus increasing the demands of praziquantel (PZQ) tablets according to the new released guideline by World Health Organization. Due to the gap between available PZQ for PC and requirements, alternative approaches to assess endemicity of schistosomiasis in a community, are urgently needed for more quick and precise methods. We aimed to find out to which degree the infection status of snails can be used to guide chemotherapy against schistosomiasis.

Methods: We searched literature published from January 1991 to December 2022, that reported on the prevalence rates of Schistosoma mansoni, S. haematobium in the intermediate snails Biomphalaria spp. and Bulinus spp., respectively, and in humans. A random effect model for meta-analyses was used to calculate the pooled prevalence estimate (PPE), with heterogeneity assessed using I-squared statistic (I2), with correlation and regression analysis for the exploration of the relationship between human S. mansoni and S. haematobium infections and that in their specific intermediate hosts.

Results: Forty-seven publications comprising 59 field investigations were included. The pooled PPE of schistosomiasis, schistosomiasis mansoni and schistosomiasis haematobium in humans were 27.5% [95% confidence interval (CI): 24.0-31.1%], 25.6% (95% CI: 19.9-31.3%), and 28.8% (95% CI: 23.4-34.3%), respectively. The snails showed an overall infection rate of 8.6% (95% CI: 7.7-9.4%), with 12.1% (95% CI: 9.9-14.2%) in the Biomphalaria spp. snails and 6.9% (95% CI: 5.7-8.1%) in the Bulinus spp. snails. The correlation coefficient was 0.3 (95% CI: 0.01-0.5%, P < 0.05) indicating that the two variables, i.e. all intermediate host snails on the one hand and the human host on the other, were positively correlated.

Conclusions: The prevalence rate of S. mansoni and S. haematobium is still high in endemic areas. Given the significant, positive correlation between the prevalence of schistosomes in humans and the intermediate snail hosts, more attention should be paid to programme integration of snail surveillance in future.

曼氏血吸虫病和血吸虫病在人类和中间钉螺宿主中的流行率和相关性:系统回顾和荟萃分析。
背景:在撒哈拉以南非洲地区,血吸虫病的控制尤为困难,该地区目前有95%的血吸虫病患者。根据世界卫生组织发布的新指南,预防性化疗(PC)的目标人群已扩大到所有有感染风险的年龄组,从而增加了对吡喹酮(PZQ)片剂的需求。由于可用于 PC 的 PZQ 与需求之间存在差距,因此急需更快速、更精确的替代方法来评估血吸虫病在社区的流行情况。我们旨在了解钉螺感染状况在多大程度上可用于指导血吸虫病化疗:我们检索了 1991 年 1 月至 2022 年 12 月期间发表的文献,这些文献分别报道了曼氏血吸虫和血吸虫在中间蜗牛 Biomphalaria spp.和 Bulinus spp.以及人类中的感染率。采用随机效应荟萃分析模型计算集合流行率估计值(PPE),用 I 平方统计量(I2)评估异质性,用相关性和回归分析探讨人类曼氏血吸虫和血吸虫感染与其特定中间宿主感染之间的关系:结果:共收录了 47 篇出版物,包括 59 项实地调查。人类血吸虫病、曼氏血吸虫病和血吸虫病的综合 PPE 分别为 27.5% [95% 置信区间 (CI):24.0-31.1%]、25.6% (95% CI:19.9-31.3%) 和 28.8% (95% CI:23.4-34.3%)。蜗牛的总体感染率为 8.6%(95% CI:7.7-9.4%),其中 Biomphalaria 属蜗牛的感染率为 12.1%(95% CI:9.9-14.2%),Bulinus 属蜗牛的感染率为 6.9%(95% CI:5.7-8.1%)。相关系数为 0.3(95% CI:0.01-0.5%,P):曼氏沙门氏菌和血吸虫在流行地区的流行率仍然很高。鉴于血吸虫在人类中的流行率与中间钉螺宿主之间存在明显的正相关关系,今后应更加重视钉螺监测计划的整合。
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来源期刊
Infectious Diseases of Poverty
Infectious Diseases of Poverty INFECTIOUS DISEASES-
自引率
1.20%
发文量
368
期刊介绍: Infectious Diseases of Poverty is an open access, peer-reviewed journal that focuses on addressing essential public health questions related to infectious diseases of poverty. The journal covers a wide range of topics including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies and application. It also considers the transdisciplinary or multisectoral effects on health systems, ecohealth, environmental management, and innovative technology. The journal aims to identify and assess research and information gaps that hinder progress towards new interventions for public health problems in the developing world. Additionally, it provides a platform for discussing these issues to advance research and evidence building for improved public health interventions in poor settings.
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