Effect of long-term inhaled corticosteroids therapy on cognitive function in patients with bronchial asthma and chronic obstructive pulmonary disease.

IF 1.3 Q4 RESPIRATORY SYSTEM

Lung India Pub Date : 2024-09-01 Epub Date: 2024-08-31 DOI:10.4103/lungindia.lungindia_399_23

Suikriti Sharma, Deepika Karki, Kanivi Julitta

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Abstract

Background: Inhaled corticosteroids (ICS) are prominent therapies for managing both asthma and chronic obstructive pulmonary disease (COPD). It has been noted that cognitive impairment is usually linked to high levels of corticosteroids in the blood.

Objective: This investigation aims to ascertain how long-term inhaled corticosteroid treatment affects individuals with bronchial asthma and COPD's cognitive performance.

Methodology: A total of 139 inpatients diagnosed with COPD and bronchial asthma were enrolled in the study of which 43 were newly diagnosed (group 1), 34 were taking ICS for 0.5-1 year (group 2) and 62 were on long-term ICS, that is, for >2 years (group 3). Patients with a score of at least 24 were considered to have normal cognitive function as prescribed by the Montreal Cognitive Assessment scale.

Result: It was observed that 56 patients (90.3%) were on long-term ICS treatment, 25 patients (73.5%) were on intermediate therapy and 27 patients (62.7%) who were newly diagnosed had cognitive impairment.

Conclusion: In conclusion, the duration of ICS therapy was significantly associated with a decline in cognitive function.

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长期吸入皮质类固醇治疗对支气管哮喘和慢性阻塞性肺病患者认知功能的影响。

背景：吸入皮质类固醇（ICS）是治疗哮喘和慢性阻塞性肺病（COPD）的主要疗法。人们注意到，认知障碍通常与血液中皮质类固醇水平过高有关：本调查旨在确定长期吸入皮质类固醇治疗如何影响支气管哮喘和慢性阻塞性肺病患者的认知能力：共有 139 名确诊为慢性阻塞性肺病和支气管哮喘的住院患者参与了研究，其中 43 人是新确诊患者（第 1 组），34 人服用 ICS 0.5-1 年（第 2 组），62 人长期服用 ICS，即超过 2 年（第 3 组）。根据蒙特利尔认知评估量表的规定，得分不低于 24 分的患者被视为认知功能正常：结果：56 名患者（90.3%）接受了长期 ICS 治疗，25 名患者（73.5%）接受了中期治疗，27 名新确诊患者（62.7%）存在认知障碍：总之，ICS 治疗时间的长短与认知功能的下降有明显关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lung India RESPIRATORY SYSTEM-

CiteScore

2.30

自引率

12.50%

发文量

114

审稿时长

37 weeks