Correlation between meibomian gland dysfunction and sebaceous adenitis in dogs.

IF 1.9 3区 农林科学 Q3 DERMATOLOGY
Veterinary dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-30 DOI:10.1111/vde.13293
Giulia Striuli, Sophie Vandenabeele, Filip Nachtegaele, Nausikaa Devriendt
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引用次数: 0

Abstract

Background: Sebaceous adenitis (SA) is an immune-mediated disease targeting the sebaceous glands. Meibomian gland dysfunction is a disease affecting meibomian glands with inflammatory features. Sebaceous and meibomian glands share anatomical, physiological and embryological similarities. The involvement of meibomian glands in dogs with SA is currently unknown.

Objectives: To evaluate meibomian glands in dogs affected by SA and compare them with healthy dogs.

Animals: Eighteen dogs were enrolled. Nine dogs with SA were retrospectively identified from clinical records and represented the case group. Nine healthy, breed- and age-matched dogs were prospectively enrolled in the control group.

Materials and methods: Both groups underwent dermatological examination, Schirmer tear test-1 (STT-1), tear meniscus height (TMH), slit-lamp biomicroscopy, interferometry (INT) and noncontact infrared meibography (NIM).

Results: One third of SA dogs presented subepithelial crystalline opacities. No significant difference between groups was observed in TMH (p = 0.944) and STT-1 values (p = 0.066). INT (p = 0.016) and NIM grades (p = 0.010) were significantly higher and lower in the SA group compared to the control group, respectively. INT values decreased with age (η = 0.930), while NIM scores (η = 0.935) increased.

Conclusions: Clinical Relevance: Subepithelial crystalline opacities in SA dogs might reflect a reduced tear film quality. In the absence of standardised methods, INT and NIM proved to be noninvasive and useful methods to examine meibomian glands. Dogs with SA showed a thinner lacrimal lipid layer and more severe meibomian gland abnormalities than control dogs, which seemed to progress with age.

狗的睑板腺功能障碍与皮脂腺炎之间的相关性。
背景:皮脂腺腺炎(SA)是一种针对皮脂腺的免疫介导疾病。睑板腺功能障碍是一种影响睑板腺并具有炎症特征的疾病。皮脂腺和睑板腺在解剖学、生理学和胚胎学上有相似之处。目前尚不清楚患有睑板腺功能障碍的犬的睑板腺是否受累:目的:评估受 SA 影响的犬的睑板腺,并将其与健康犬进行比较:动物:18只狗参加了研究。从临床记录中回顾性地确定了 9 只患有睑板腺囊肿的狗作为病例组。材料和方法:两组狗都接受了皮肤病学检查:两组犬均接受了皮肤病检查、施尔默泪液测试-1(STT-1)、泪液半月板高度(TMH)、裂隙灯生物显微镜检查、干涉测量法(INT)和非接触式红外线眼底照相术(NIM):三分之一的 SA 犬出现上皮下结晶不透明。各组之间的 TMH 值(p = 0.944)和 STT-1 值(p = 0.066)无明显差异。与对照组相比,SA 组的 INT(p = 0.016)和 NIM 等级(p = 0.010)分别明显较高和较低。INT值随着年龄的增长而降低(η = 0.930),而NIM评分(η = 0.935)则有所增加:临床意义:SA 犬的上皮下结晶不透明可能反映了泪膜质量的下降。在缺乏标准化方法的情况下,INT 和 NIM 被证明是检查睑板腺的非侵入性有用方法。与对照组犬相比,SA 犬的泪腺脂质层更薄,睑板腺异常更严重,而且似乎会随着年龄的增长而加重。
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来源期刊
Veterinary dermatology
Veterinary dermatology 农林科学-兽医学
CiteScore
3.20
自引率
21.40%
发文量
92
审稿时长
12-24 weeks
期刊介绍: Veterinary Dermatology is a bi-monthly, peer-reviewed, international journal which publishes papers on all aspects of the skin of mammals, birds, reptiles, amphibians and fish. Scientific research papers, clinical case reports and reviews covering the following aspects of dermatology will be considered for publication: -Skin structure (anatomy, histology, ultrastructure) -Skin function (physiology, biochemistry, pharmacology, immunology, genetics) -Skin microbiology and parasitology -Dermatopathology -Pathogenesis, diagnosis and treatment of skin diseases -New disease entities
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