Targeted precision cryotherapy for acne vulgaris.

IF 2 4区医学 Q3 DERMATOLOGY

Skin Research and Technology Pub Date : 2024-09-01 DOI:10.1111/srt.70045

Ji Yeon Hong, Ka Ram Kim, Hyun Jung Kim, Joon Seok, Kui Young Park

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引用次数: 0

Abstract

Background: Acne vulgaris poses a significant dermatological challenge, necessitating alternative treatments due to limitations and side effects associated with current therapies. This pilot clinical trial investigated the feasibility and efficacy of precision cryotherapy for acne vulgaris.

Methods: A total of 20 volunteers underwent targeted precision cryotherapy using a carbon dioxide-based device. Treatment outcomes were assessed using various parameters, including Investigator Global Assessment (IGA) score, acne lesion count, erythema index (EI), global evaluation score, and participant satisfaction. Safety monitoring included adverse event reporting and physical examination.

Results: Precision cryotherapy demonstrated a significant reduction (90.25%) in the acne lesion count by week 4, with clinical improvement indicated by IGA score reduction (p < 0.001). The EI showed notable improvements at weeks 1, 2, and 4. The global evaluation score demonstrated a 75%-100% clinical improvement at Visit 4. Participants reported high satisfaction (6.75 ± 0.79) with the procedure. No adverse event or discomfort was reported.

Conclusion: Precision cryotherapy effectively improved acne lesions, which was safe and satisfactory for participants. These findings suggest its potential as an alternative therapeutic modality, especially for populations with limited treatment options. Further research is needed to validate the results and explore underlying mechanisms.

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针对寻常型痤疮的精准冷冻疗法。

背景：寻常型痤疮是皮肤科面临的一项重大挑战，由于现有疗法的局限性和副作用，有必要采用替代疗法。这项试点临床试验研究了精确冷冻疗法治疗寻常型痤疮的可行性和疗效：方法：共有 20 名志愿者接受了使用二氧化碳设备的靶向精确冷冻疗法。治疗结果通过各种参数进行评估，包括研究者总体评估（IGA）得分、痤疮皮损计数、红斑指数（EI）、总体评估得分和参与者满意度。安全性监测包括不良事件报告和身体检查：结果：精确冷冻疗法在第 4 周时显著减少了痤疮皮损数量（90.25%），IGA 评分的降低表明临床症状有所改善（p 结论：精确冷冻疗法有效地改善了痤疮的症状：精确冷冻疗法能有效改善痤疮皮损，对参与者来说是安全和令人满意的。这些研究结果表明，精确冷冻疗法具有作为替代治疗方法的潜力，尤其适合治疗选择有限的人群。还需要进一步的研究来验证结果并探索其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.