Role of the pontine respiratory group in the suppression of cough by codeine in cats

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-28 DOI:10.1016/j.resp.2024.104326

Michal Simera, Denisa Berikova, Ole-Jacob Hovengen, Marek Laheye, Marcel Veternik, Lukas Martvon , Zuzana Kotmanova, Lucia Cibulkova, Ivan Poliacek

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Abstract

Codeine was microinjected into the area of the Kölliker-Fuse nucleus and the adjacent lateral parabrachial nucleus, within the pontine respiratory group in 8 anesthetized cats. Electromyograms (EMGs) of the diaphragm (DIA) and abdominal muscles (ABD), esophageal pressures (EP), and blood pressure were recorded and analyzed during mechanically induced tracheobronchial cough. Unilateral microinjections of 3.3 mM codeine (3 injections, each 37 ± 1.2 nl) had no significant effect on the cough number. However, the amplitudes of the cough ABD EMG, expiratory EP and, to a lesser extent, DIA EMG were significantly reduced. There were no significant changes in the temporal parameters of the cough. Control microinjections of artificial cerebrospinal fluid in 6 cats did not show a significant effect on cough data compared to those after codeine microinjections. Codeine-sensitive neurons in the rostral dorsolateral pons contribute to controlling cough motor output, likely through the central pattern generator of cough.

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可待因在抑制猫咳嗽中的脑桥呼吸群作用

在 8 只麻醉猫的桥脑呼吸群中，向 Kölliker-Fuse 神经核区域和邻近的外侧腋旁神经核微量注射可待因。在机械诱导气管支气管咳嗽期间，记录并分析了膈肌（DIA）和腹肌（ABD）的肌电图（EMG）、食管压力（EP）和血压。单侧微量注射 3.3mM 可待因（3 次，每次 37 ± 1.2nl）对咳嗽次数无明显影响。但是，咳嗽 ABD EMG、呼气 EP 的振幅明显减小，DIA EMG 的振幅也有一定程度的减小。咳嗽的时间参数没有明显变化。与可待因微量注射后的咳嗽数据相比，6 只猫的人工脑脊液对照微量注射对咳嗽数据没有明显影响。喙背外侧脑桥的可待因敏感神经元可能通过咳嗽中枢模式发生器控制咳嗽运动输出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.