Advancement in the Antigenic Epitopes and Vaccine Adjuvants of African Swine Fever Virus.

IF 3.3 3区医学 Q2 MICROBIOLOGY

Pathogens Pub Date : 2024-08-21 DOI:10.3390/pathogens13080706

Qiong Wu, Chang Li, Bo Zhu, Jiajia Zhu, Keli Yang, Zewen Liu, Wei Liu, Ting Gao, Fangyan Yuan, Rui Guo, Yongxiang Tian, Danna Zhou

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Abstract

African swine fever virus (ASFV), a highly virulent double-stranded DNA virus, poses a significant threat to global pig farming, with mortality rates in domestic pigs reaching up to 100%. Originating in Kenya in 1921, ASFV has since proliferated to Western Europe, Latin America, Eastern Europe, and most recently China in 2018, resulting in substantial global agricultural losses. Antigenic epitopes, recognized by the immune system's T cells and B cells, are pivotal in antiviral immune responses. The identification and characterization of these antigenic epitopes can offer invaluable insights into the immune response against ASFV and aid in the development of innovative immunotherapeutic strategies. Vaccine adjuvants, substances that amplify the body's specific immune response to antigens, also play a crucial role. This review provides an overview of the progress in studying T/B-cell epitopes in ASFV proteins and ASFV vaccine adjuvants, highlighting their role in the immune response and potential use in new vaccine development.

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非洲猪瘟病毒抗原表位和疫苗佐剂的研究进展。

非洲猪瘟病毒（ASFV）是一种高致病性双链DNA病毒，对全球养猪业构成重大威胁，家猪死亡率高达100%。ASFV 于 1921 年起源于肯尼亚，之后扩散到西欧、拉丁美洲、东欧，最近于 2018 年扩散到中国，造成了巨大的全球农业损失。免疫系统的 T 细胞和 B 细胞识别的抗原表位在抗病毒免疫反应中起着关键作用。这些抗原表位的鉴定和特征描述可为了解抗 ASFV 的免疫反应提供宝贵的信息，并有助于开发创新的免疫治疗策略。疫苗佐剂（可增强机体对抗原的特异性免疫反应的物质）也发挥着至关重要的作用。本综述概述了 ASFV 蛋白和 ASFV 疫苗佐剂中 T/B 细胞表位的研究进展，强调了它们在免疫反应中的作用以及在新疫苗开发中的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathogens Medicine-Immunology and Allergy

CiteScore

6.40

自引率

8.10%

发文量

1285

审稿时长

17.75 days

期刊介绍： Pathogens (ISSN 2076-0817) publishes reviews, regular research papers and short notes on all aspects of pathogens and pathogen-host interactions. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.

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