Population-Based Incidence and Clinical Characteristics of Ocular Adnexal Tumors in Olmsted County, Minnesota.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

Ophthalmic epidemiology Pub Date : 2024-08-30 DOI:10.1080/09286586.2024.2379971

Kenny Y Wang, Timothy T Xu, Mihai G Dumbrava, Kafayat A Oyemade, Johanny Lopez Dominguez, David O Hodge, Launia J White, Andrea A Tooley, Lauren A Dalvin

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Abstract

Purpose: To determine the incidence and clinical characteristics of ocular adnexaltumors in Olmsted County, Minnesota.

Methods: Retrospective population-based cohort study of all patients residing in Olmsted County, Minnesota diagnosed with any ocular tumor from January 1, 2006, to December 31, 2015. The medical records of all patients with an incident diagnosis of any ocular adnexal tumor were reviewed using the Rochester Epidemiology Project medical record linkage system for patient demographics, tumor type, and histopathologic confirmation. Incidence rates were calculated per 100,000 person-years. Poisson regression analysis was used to analyze changes in incidence over time.

Results: There were 717 patients diagnosed with ocular adnexal tumors during the 10-year study period, yielding an age- and sex-adjusted incidence rate of 59.7 per 100,000 (95% CI 55.4 to 64.0, p < 0.05) per year. In total, 764 tumors were diagnosed. Most tumors were eyelid lesions (N = 756, 99.0%), which were mostly benign (N = 512, 67.8%) with epidermal inclusion cysts (N = 275, 36.0%), hidrocystoma (N = 70, 9.2%), and eyelid sebaceous cysts (N = 46, 6.1%) accounting for the majority. Malignant eyelid lesions (N = 244, 31.9%) were relatively common with basal cell carcinoma (N = 184, 24.1%) and squamous cell carcinoma (N = 49, 6.4%) having the highest frequencies. Orbital tumors (N = 8, 1.0%) were infrequent. Of the orbital tumors, the most common was lacrimal gland adenoidcystic carcinoma (N = 2, 25.0%).

Conclusions: In a population-based setting, most ocular adnexal tumors were benign eyelid lesions. Understanding the epidemiology of ocular adnexal tumors is important to aid providers in diagnosing and facilitating appropriate referrals of potentially vision- and life-threatening malignancies.

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明尼苏达州奥姆斯特德县眼部附件肿瘤的人群发病率和临床特征。

目的：确定明尼苏达州奥姆斯特德县眼部附件肿瘤的发病率和临床特征：方法：对居住在明尼苏达州奥姆斯特德县的 2006 年 1 月 1 日至 2015 年 12 月 31 日期间确诊患有任何眼部肿瘤的所有患者进行基于人群的回顾性队列研究。研究人员使用罗切斯特流行病学项目（Rochester Epidemiology Project）病历链接系统对所有被诊断为眼部附件肿瘤的患者的病历进行了审查，以了解患者的人口统计学特征、肿瘤类型和组织病理学证实。发病率按每 10 万人年计算。采用泊松回归分析法分析发病率随时间的变化：结果：在 10 年的研究期间，共有 717 名患者被诊断为眼部附件肿瘤，经年龄和性别调整后的发病率为每 10 万人中 59.7 例（95% CI 55.4 至 64.0，P N = 756，99.0%），其中大部分为良性病变（N = 512，67.8%），表皮包涵囊肿（N = 275，36.0%）、息肉囊肿（N = 70，9.2%）和眼睑皮脂腺囊肿（N = 46，6.1%）占大多数。眼睑恶性病变（244 例，31.9%）相对常见，其中基底细胞癌（184 例，24.1%）和鳞状细胞癌（49 例，6.4%）发病率最高。眼眶肿瘤（8 例，1.0%）并不常见。在眼眶肿瘤中，最常见的是泪腺腺样囊性癌（2 例，25.0%）：结论：在以人群为基础的环境中，大多数眼部附件肿瘤是眼睑良性病变。了解眼部附件肿瘤的流行病学非常重要，有助于医疗服务提供者对可能危及视力和生命的恶性肿瘤进行诊断和适当转诊。

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来源期刊

Ophthalmic epidemiology 医学-眼科学

CiteScore

3.70

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.