Epithelial‑derived head and neck squamous tumourigenesis (Review).

IF 3.8 3区 医学 Q2 ONCOLOGY
Oncology reports Pub Date : 2024-10-01 Epub Date: 2024-09-02 DOI:10.3892/or.2024.8800
Charles Adolfu Shirima, Coralia Bleotu, Demetrios A Spandidos, Adel K El-Naggar, Gratiela Gradisteanu Pircalabioru, Ioannis Michalopoulos
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引用次数: 0

Abstract

Head and neck squamous cell carcinomas (HNSCCs), a heterogeneous group of cancers that arise from the mucosal epithelia cells in the head and neck areas, present great challenges in diagnosis, treatment and prognosis due to their complex aetiology and various clinical manifestations. Several factors, including smoking, alcohol consumption, oncogenic genes, growth factors, Epstein‑Barr virus and human papillomavirus infections can contribute to HNSCC development. The unpredictable tumour microenvironment adds to the complexity of managing HNSCC. Despite significant advances in therapies, the prediction of outcome after treatment for patients with HNSCC remains poor, and the 5‑year overall survival rate is low due to late diagnosis. Early detection greatly increases the chances of successful treatment. The present review aimed to bring together the latest findings related to the molecular mechanisms of HNSCC carcinogenesis and progression. Comprehensive genomic, transcriptomic, metabolomic, microbiome and proteomic analyses allow researchers to identify important biological markers such as genetic alterations, gene expression signatures and protein markers that drive HNSCC tumours. These biomarkers associated with the stages of initiation, progression and metastasis of cancer are useful in the management of patients with cancer in order to improve their life expectancy and quality of life.

上皮源性头颈部鳞状肿瘤发生(综述)。
头颈部鳞状细胞癌(HNSCC)是一类由头颈部粘膜上皮细胞引发的异质性癌症,由于其病因复杂、临床表现多样,给诊断、治疗和预后带来了巨大挑战。吸烟、饮酒、致癌基因、生长因子、Epstein-Barr 病毒和人类乳头瘤病毒感染等多种因素都可能导致 HNSCC 的发生。不可预测的肿瘤微环境增加了治疗 HNSCC 的复杂性。尽管疗法取得了重大进展,但对 HNSCC 患者治疗后的预后预测仍然很差,而且由于诊断较晚,5 年总生存率很低。早期发现可大大增加治疗成功的几率。本综述旨在汇集与 HNSCC 癌变和进展的分子机制相关的最新研究成果。通过全面的基因组、转录组、代谢组、微生物组和蛋白质组分析,研究人员可以确定驱动 HNSCC 肿瘤的重要生物标志物,如基因改变、基因表达特征和蛋白质标志物。这些与癌症发生、发展和转移阶段相关的生物标志物有助于癌症患者的管理,从而提高他们的预期寿命和生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Oncology reports
Oncology reports 医学-肿瘤学
CiteScore
8.50
自引率
2.40%
发文量
187
审稿时长
3 months
期刊介绍: Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.
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