Ping Zheng, Shunmin Yang, Dabin Ren, Xiaoxue Zhang, Qingke Bai
{"title":"A Pan-Cancer Analysis of the Oncogenic Role of Methyltransferase-Like 1 in Human Tumors.","authors":"Ping Zheng, Shunmin Yang, Dabin Ren, Xiaoxue Zhang, Qingke Bai","doi":"10.4103/neurol-india.ni_1354_21","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and object: </strong>Although emerging cell- or animal-based evidence supports the relationship between methyltransferase-like 1 (METTL1) and cancers, no pan-cancer analysis is available.</p><p><strong>Methods: </strong>We thus first explored the potential oncogenic roles of METTL1 across 33 tumors based on the datasets of The Cancer Genome Atlas and Gene Expression Omnibus.</p><p><strong>Results: </strong>METTL1 is highly expressed in most cancers, and distinct associations exist between METTL1 expression and prognosis of tumor patients. METTL1 level is related with the dendritic and B-cell infiltration levels in most tumors. Moreover, RNA processing- and RNA metabolism-associated functions were involved in the functional mechanisms of METTL1.</p><p><strong>Conclusion: </strong>Our pan-cancer study offers a relatively comprehensive understanding of the oncogenic roles of METTL1 across different tumors.</p>","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurology India","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/neurol-india.ni_1354_21","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/31 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background and object: Although emerging cell- or animal-based evidence supports the relationship between methyltransferase-like 1 (METTL1) and cancers, no pan-cancer analysis is available.
Methods: We thus first explored the potential oncogenic roles of METTL1 across 33 tumors based on the datasets of The Cancer Genome Atlas and Gene Expression Omnibus.
Results: METTL1 is highly expressed in most cancers, and distinct associations exist between METTL1 expression and prognosis of tumor patients. METTL1 level is related with the dendritic and B-cell infiltration levels in most tumors. Moreover, RNA processing- and RNA metabolism-associated functions were involved in the functional mechanisms of METTL1.
Conclusion: Our pan-cancer study offers a relatively comprehensive understanding of the oncogenic roles of METTL1 across different tumors.
期刊介绍:
Neurology India (ISSN 0028-3886) is Bi-monthly publication of Neurological Society of India. Neurology India, the show window of the progress of Neurological Sciences in India, has successfully completed 50 years of publication in the year 2002. ‘Neurology India’, along with the Neurological Society of India, has grown stronger with the passing of every year. The full articles of the journal are now available on internet with more than 20000 visitors in a month and the journal is indexed in MEDLINE and Index Medicus, Current Contents, Neuroscience Citation Index and EMBASE in addition to 10 other indexing avenues.
This specialty journal reaches to about 2000 neurologists, neurosurgeons, neuro-psychiatrists, and others working in the fields of neurology.