Neuromyelitis optica spectrum disorder mimicking cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy with symmetrical lesions in the temporal poles and external capsules on MRI.

IF 2.4 3区医学 Q2 CLINICAL NEUROLOGY

Neuroradiology Pub Date : 2024-11-01 Epub Date: 2024-08-29 DOI:10.1007/s00234-024-03458-0

Yasuyuki Kojita, Atsushi K Kono, Takahiro Yamada, Minoru Yamada, Sung-Woon Im, Takenori Kozuka, Hayato Kaida, Motoi Kuwahara, Yoshitaka Nagai, Kazunari Ishii

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Abstract

Symmetrical lesions in the temporal poles and external capsules on brain MRI are known as radiological markers of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); however, similar imaging findings have also been reported in neuromyelitis optica spectrum disorder (NMOSD), and this study investigated the frequency of such findings. The study included 55 NMOSD patients who met the 2015 international NMO diagnosis panel (IPND) criteria and were positive for aquaporin-4 antibodies (AQP4-Ab). Images were evaluated based on the consensus of two neuroradiologists, and brain lesions were detected in 33 patients, of whom 2 (6%) had symmetrical lesions in both the temporal poles and external capsules, and 1 (3%) had symmetrical lesions confined to the external capsules. Therefore, when symmetrical lesions in the temporal poles and external capsules are observed on MRI, NMOSD should be considered in the differential diagnosis.

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神经脊髓炎视网膜频谱紊乱症模仿大脑常染色体显性动脉病，伴有皮层下梗塞和白质脑病，核磁共振成像显示颞极和外囊有对称性病变。

众所周知，脑磁共振成像（MRI）上颞极和外囊的对称性病变是脑常染色体显性动脉病伴有皮层下梗死和白质脑病（CADASIL）的放射学标志；然而，神经性脊髓炎视网膜频谱障碍（NMOSD）中也有类似的影像学发现，本研究对此类发现的频率进行了调查。研究纳入了55名符合2015年国际NMO诊断小组（IPND）标准且水通道蛋白-4抗体（AQP4-Ab）阳性的NMOSD患者。根据两名神经放射学专家的共识对图像进行了评估，发现33名患者存在脑部病变，其中2人（6%）的对称性病变位于颞极和外囊，1人（3%）的对称性病变仅限于外囊。因此，当 MRI 观察到颞极和外囊有对称性病变时，NMOSD 应在鉴别诊断中予以考虑。

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来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.