Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia.

IF 2.6 3区 心理学 Q3 NEUROSCIENCES
Neuropsychology Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI:10.1037/neu0000969
Troy A Webber, Steven P Woods, Sara A Lorkiewicz, Holley W Yazbeck, Elaine R Schultz, Andrew M Kiselica
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引用次数: 0

Abstract

Objective: Executive dysfunction is characteristic of behavioral variant frontotemporal dementia (bvFTD) but can be challenging to detect. Dispersion-based intraindividual variability (IIV-d) is hypothesized to reflect a sensitive index of executive dysfunction and has demonstrated relevance to functional decline but has not been evaluated in bvFTD.

Method: We report on 477 demographically matched participants (159 cognitively healthy [CH], 159 clinical Alzheimer's disease [AD], 159 clinical bvFTD/prodromal bvFTD) who completed the Uniform Data Set 3.0 Neuropsychological Battery. IIV-d was measured using the coefficient of variance (CoV; raw and demographically adjusted) across 12 Uniform Data Set 3.0 Neuropsychological Battery indicators and the informant-rated Functional Activities Questionnaire assessed daily functioning.

Results: Analysis of covariance showed that participants in the bvFTD/prodromal bvFTD group exhibited higher raw and demographically adjusted CoV compared to CH participants, at a very large effect size (d = 1.28-1.47). Demographically adjusted (but not raw) CoV was lower in the bvFTD/prodromal bvFTD group than the AD group, though the effect size was small (d = .38). Both CoV metrics accurately differentiated the bvFTD/prodromal bvFTD and CH groups (areas under the curve = .84), but not bvFTD/prodromal bvFTD and AD groups (areas under the curve = .59). Regression analyses in the bvFTD/prodromal bvFTD group indicated that higher IIV-d on both metrics was associated with greater daily functioning impairment, over and above covariates.

Conclusions: Compared to healthy adults, individuals with bvFTD/prodromal bvFTD show greater levels of performance variability across a battery of neuropsychological measures, which interferes with everyday functioning. These data demonstrate the clinical utility and ecological validity of IIV-d in bvFTD/prodromal bvFTD, though these findings should be replicated in more diverse samples. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

行为变异型额颞叶痴呆症和前驱行为变异型额颞叶痴呆症的认知分散及其功能相关性。
目的:执行功能障碍是行为变异性额颞叶痴呆症(bvFTD)的特征,但检测起来却很困难。基于离散度的个体内变异性(IIV-d)被假定为反映执行功能障碍的敏感指标,并已被证明与功能衰退相关,但尚未在bvFTD中进行评估:我们报告了完成统一数据集 3.0 神经心理测试的 477 名人口统计学匹配参与者(159 名认知健康者 [CH]、159 名临床阿尔茨海默病患者 [AD]、159 名临床 bvFTD/前驱 bvFTD)的情况。IIV-d采用12项统一数据集3.0神经心理测验指标的方差系数(CoV;原始数据和人口统计学调整后数据)进行测量,由线人评定的功能活动问卷对日常功能进行评估:协方差分析表明,bvFTD/前驱bvFTD组的参与者与CH组的参与者相比,表现出更高的原始CoV和经人口统计学调整的CoV,其效应大小非常大(d = 1.28-1.47)。bvFTD/prodromal bvFTD 组经人口统计学调整的 CoV(而非原始 CoV)低于 AD 组,但效应大小较小(d = 0.38)。两种 CoV 指标都能准确区分 bvFTD/前驱 bvFTD 组和 CH 组(曲线下面积 = .84),但不能区分 bvFTD/前驱 bvFTD 组和 AD 组(曲线下面积 = .59)。bvFTD/prodromal bvFTD组的回归分析表明,两项指标的IIV-d越高,日常功能损害越大,超过了协变量:结论:与健康成年人相比,bvFTD/前驱bvFTD患者在一系列神经心理测量中表现出更大的变异性,从而影响了日常功能。这些数据证明了IIV-d在bvFTD/萌芽期bvFTD患者中的临床实用性和生态学有效性,尽管这些研究结果应该在更多不同的样本中得到重复。(PsycInfo Database Record (c) 2024 APA,保留所有权利)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neuropsychology
Neuropsychology 医学-神经科学
CiteScore
4.10
自引率
4.20%
发文量
132
审稿时长
6-12 weeks
期刊介绍: Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.
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