Causal Relationship Between Micronutrient and Sleep Disorder: A Mendelian Randomization Study.

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI:10.2147/NSS.S475171

Yingying Jiang, Siqi Ge, Chunyang Wang, Chen Jin, Yumei Zhao, Qingying Liu

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引用次数: 0

Abstract

Background: Sleep played an important part in human health, and COVID-19 led to a continuous deterioration of sleep. However, the causal relationship between micronutrient and sleep disorder was not yet fully understood.

Methods: In this research, the genetic causal relationship between micronutrient and sleep disorder was analyzed utilizing a two-sample Mendelian randomization (MR). Single nucleotide polymorphisms (SNPs) were used as instrumental variables. The analyses were conducted using the MR-Egger, inverse variance weighted, weighted mode, weighted median, simple mode, Cochran's Q test and leave-one-out.

Results: Our results suggested that 8 genetically predicted micronutrients participated in sleep disorders, including liver iron (L-iron) and iron in sleeping too much, spleen iron (S-iron) in sleeplessness/insomnia, trouble falling or staying asleep, sleep duration (undersleepers) and nonorganic sleeping disorders, iron metabolism disorder (IMD) and vitamin B12 deficiency anaemia (VB12DA) in narcolepsy, urine sodium (uNa) in narcolepsy, sleep apnea syndrome and sleep disorder, vitamin D (VD) in sleep duration (oversleepers), 25-Hydroxyvitamin D (25(OH)D) in trouble falling or staying asleep.

Conclusion: Our study used Mendelian randomization methods at the SNP level to explore the potential causal relationship among L-iron, iron, S-iron, IMD, uNa, 25(OH)D, VD, VB12DA with certain sleep disorder subtypes. Our results uncovered a micronutrient-based strategy for alleviating sleep disorder symptoms.

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微量营养素与睡眠障碍之间的因果关系：孟德尔随机研究》。

背景：睡眠对人类健康非常重要，COVID-19导致睡眠持续恶化。然而，微量营养素与睡眠障碍之间的因果关系尚未完全明了：本研究采用双样本孟德尔随机法（MR）分析了微量营养素与睡眠障碍之间的遗传因果关系。单核苷酸多态性（SNPs）被用作工具变量。分析采用了 MR-Egger、逆方差加权、加权模式、加权中位数、简单模式、Cochran's Q 检验和 leave-one-out 等方法：结果：我们的研究结果表明，8种基因预测的微量营养素参与了睡眠障碍，包括肝铁（L-铁）和睡得太多的铁、脾铁（S-铁）与睡眠不足/失眠、入睡或保持睡眠困难、睡眠持续时间（睡眠不足者）和非器质性睡眠障碍有关、铁代谢紊乱（IMD）和维生素 B12 缺乏性贫血（VB12DA）与嗜睡症，尿钠（uNa）与嗜睡症、睡眠呼吸暂停综合征和睡眠障碍，维生素 D（VD）与睡眠时间（睡眠过多者），25-羟维生素 D（25(OH)D）与入睡或保持睡眠困难。结论我们的研究在SNP水平上采用孟德尔随机方法，探讨了左旋铁、铁、S-铁、IMD、uNa、25（OH）D、VD、VB12DA与某些睡眠障碍亚型之间的潜在因果关系。我们的研究结果揭示了一种基于微量营养素的缓解睡眠障碍症状的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.