The refined Pathways to Cures Research Roadmap for multiple sclerosis cures.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI:10.1177/13524585241266483

Bruce F Bebo, Brenda L Banwell, Caroline C Whitacre, Timothy Coetzee, Ulrik Dalgas, Phillip L De Jager, Anne-Katrin Proebstel, V Wee Yong, Etty N Benveniste, Alan J Thompson

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引用次数: 0

Abstract

Background: Multiple sclerosis is a chronic immune-mediated disease of the central nervous system affecting nearly 3 million people worldwide. Although much progress has been made in the understanding and treatment of MS, cures remain elusive.

Objectives: To accelerate the development of cures for MS by updating the Pathways to Cures Research Roadmap based on a contemporary understanding of disease. The refined Roadmap will help to promote research in scientific areas with great potential to reveal insights leading to cures and inspire greater coordination of global resources.

Methods: Refinements to the Roadmap were achieved during a Global Summit that included close to 200 academic and industry scientists, health care providers, policy makers, funders, and people with MS from 15 countries.

Results: The refined Roadmap describes three pathways that target opportunities for generating scientific insights leading to cures. Recommendations for accelerating research progress include, lowering barriers for global data sharing, enhancing collaboration and coordination among research supporters, committing to sustained funding, considering implications for implementation, engaging PwMS and committing to diversity, equity, and inclusion in the global MS movement.

Conclusion: The refined roadmap provides a strategic framework for tackling the complexities of MS and advancing prevention strategies, effective treatments, and cures.

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完善的多发性硬化症治疗研究路线图。

背景：多发性硬化症是一种由免疫介导的慢性中枢神经系统疾病，影响着全球近 300 万人。虽然在多发性硬化症的认识和治疗方面取得了很大进展，但治愈方法仍然遥遥无期：目标：根据对疾病的现代认识，更新 "治愈之路研究路线图"，从而加快多发性硬化症治愈方法的开发。改进后的路线图将有助于促进具有巨大潜力的科学领域的研究，从而揭示治疗方法，并促进全球资源的进一步协调：方法：在全球峰会期间对路线图进行了完善，来自 15 个国家的近 200 名学术界和产业界科学家、医疗服务提供者、政策制定者、资助者和多发性硬化症患者参加了此次峰会：成果：完善后的路线图描述了三条途径，这些途径针对的是产生科学见解从而实现治愈的机会。加快研究进展的建议包括：降低全球数据共享的障碍，加强研究支持者之间的合作与协调，承诺持续提供资金，考虑实施的影响，让多发性硬化症患者参与进来，并承诺在全球多发性硬化症运动中实现多样性、公平性和包容性：完善后的路线图为应对多发性硬化症的复杂性、推进预防战略、有效治疗和治愈提供了战略框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585