Abnormal brain-heart electrophysiology in mild and severe orthostatic hypotension.

IF 3.3 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Journal of Hypertension Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI:10.1097/HJH.0000000000003838

Yingzhe Cheng, Peilin Huang, Lin Lin, Jiejun Zhang, Yahui Cheng, Jiahao Zheng, Yanping Wang, Xiaodong Pan

{"title":"Abnormal brain-heart electrophysiology in mild and severe orthostatic hypotension.","authors":"Yingzhe Cheng, Peilin Huang, Lin Lin, Jiejun Zhang, Yahui Cheng, Jiahao Zheng, Yanping Wang, Xiaodong Pan","doi":"10.1097/HJH.0000000000003838","DOIUrl":null,"url":null,"abstract":"Introduction: This study investigated the changes in cardiocerebral electrophysiology in patients with mild orthostatic hypotension (MOH) and severe orthostatic hypotension (SOH) and their relationship with the severity of orthostatic hypotension, psychiatric symptoms, and cognitive dysfunction.Methods: This study included 72 nonorthostatic hypotension (NOH), 17 with MOH, and 11 with SOH. Seated resting-state heart rate variability (HRV) and quantitative electroencephalogram parameters were synchronized and recorded. HRV measures in the time and frequency domains were analyzed, along with the peak frequency and power of the brain waves.Results: Abnormal neuronal activity was found in FP1 in patients with MOH, whereas it was more widespread in FP1, FP2, and O2 in patients with SOH ( P < 0.05). Cardiac and cerebral electrophysiological abnormalities were significantly associated with orthostatic hypotension severity, psychiatric symptoms, and cognitive dysfunction.Conclusion: Abnormal EEG activity in patients are mainly manifested in the prefrontal and occipital lobes, especially in patients with SOH. These results may help patients to better understand the mechanisms underlying orthostatic hypotension severity and psychiatric and cognitive impairment in orthostatic hypotension.","PeriodicalId":16043,"journal":{"name":"Journal of Hypertension","volume":" ","pages":"2094-2106"},"PeriodicalIF":3.3000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hypertension","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/HJH.0000000000003838","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/29 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: This study investigated the changes in cardiocerebral electrophysiology in patients with mild orthostatic hypotension (MOH) and severe orthostatic hypotension (SOH) and their relationship with the severity of orthostatic hypotension, psychiatric symptoms, and cognitive dysfunction.

Methods: This study included 72 nonorthostatic hypotension (NOH), 17 with MOH, and 11 with SOH. Seated resting-state heart rate variability (HRV) and quantitative electroencephalogram parameters were synchronized and recorded. HRV measures in the time and frequency domains were analyzed, along with the peak frequency and power of the brain waves.

Results: Abnormal neuronal activity was found in FP1 in patients with MOH, whereas it was more widespread in FP1, FP2, and O2 in patients with SOH ( P < 0.05). Cardiac and cerebral electrophysiological abnormalities were significantly associated with orthostatic hypotension severity, psychiatric symptoms, and cognitive dysfunction.

Conclusion: Abnormal EEG activity in patients are mainly manifested in the prefrontal and occipital lobes, especially in patients with SOH. These results may help patients to better understand the mechanisms underlying orthostatic hypotension severity and psychiatric and cognitive impairment in orthostatic hypotension.

查看原文本刊更多论文

轻度和重度正张性低血压的脑心电生理学异常。

简介本研究探讨了轻度正张力性低血压（MOH）和重度正张力性低血压（SOH）患者的心脑电生理学变化及其与正张力性低血压严重程度、精神症状和认知功能障碍的关系：这项研究包括 72 名非正张性低血压（NOH）患者、17 名 MOH 患者和 11 名 SOH 患者。对坐位静息状态心率变异性（HRV）和定量脑电图参数进行了同步记录。对时域和频域的心率变异测量值以及脑电波的峰值频率和功率进行了分析：结果：在 MOH 患者的 FP1 中发现了异常的神经元活动，而在 SOH 患者的 FP1、FP2 和 O2 中则发现了更广泛的异常活动：患者的异常脑电活动主要表现在前额叶和枕叶，尤其是在 SOH 患者中。这些结果可能有助于患者更好地了解正性低血压严重程度以及正性低血压的精神和认知障碍的内在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Hypertension 医学-外周血管病

CiteScore

7.90

自引率

6.10%

发文量

1389

审稿时长

3 months

期刊介绍： The Journal of Hypertension publishes papers reporting original clinical and experimental research which are of a high standard and which contribute to the advancement of knowledge in the field of hypertension. The Journal publishes full papers, reviews or editorials (normally by invitation), and correspondence.