Fetal echogenic bowel may be related to intestinal microbiota: A prospective cohort study.

IF 1.2 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2024-11-01 Epub Date: 2024-08-30 DOI:10.1002/jcu.23794

Yanping Zhao, Guorong Lyu

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引用次数: 0

Abstract

Objective: The purpose of the current study was to determine the difference in intestinal microbiota after delivery between healthy fetuses and fetuses with hyperechogenic bowel during the second trimester and the relationship between fetal echogenic bowel and microbiota.

Methods: Fourteen healthy fetuses (control group), 13 fetuses with echogenic bowel (EB group), and seven fetuses with echogenic bowel and other abnormalities (C-EB group) were selected. The first meconium after delivery was collected for 16S rRNA sequencing.

Results: A total of 1 222 131 high-quality sequences were generated after sequencing optimization of all samples. Each sample contained an average of 35 945 high-quality sequences and 2036 operational taxonomic units (OTUs). There was no significant difference in the Shannon, Simpson index among the three groups. At the genus level, the abundance of Escherichia coli/Shigella in the EB and C-EB groups was significantly lower than the control group, while the abundance of Staphylococcus, Methylobactrium, and Curvibacter in the EB group was significantly higher than the other groups. There was a difference in abundance of Gammaproteobacteria, Fusobacteria, Enterobacteriaceae, and E. coli in the EB and C-EB groups.

Conclusions: The formation of echogenic bowel may be related to the microbiota.

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胎儿回声肠可能与肠道微生物群有关：一项前瞻性队列研究

研究目的本研究旨在确定健康胎儿和妊娠后三个月肠回声过高胎儿产后肠道微生物区系的差异，以及胎儿肠回声与微生物区系之间的关系：选取14名健康胎儿（对照组）、13名肠回声异常胎儿（EB组）和7名肠回声异常及其他异常胎儿（C-EB组）。采集分娩后的第一次胎粪进行 16S rRNA 测序：结果：对所有样本进行测序优化后，共获得 1 222 131 个高质量序列。每个样本平均包含 35 945 条高质量序列和 2036 个操作分类单元（OTU）。三组样本的香农、辛普森指数无明显差异。在菌属水平上，EB 组和 C-EB 组中大肠杆菌/志贺氏菌的丰度明显低于对照组，而 EB 组中葡萄球菌、甲型杆菌和卷曲杆菌的丰度明显高于其他组。EB组和C-EB组的伽马变形杆菌、镰刀菌、肠杆菌科细菌和大肠杆菌的数量存在差异：结论：回声肠的形成可能与微生物群有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.