Role of the lncRNA/Wnt signaling pathway in digestive system cancer: a literature review.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-09-02 DOI:10.1186/s40001-024-02033-w

Penghui Li, Xiao Ma, Di Huang

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引用次数: 0

Abstract

The long noncoding RNA (lncRNA)/Wingless (Wnt) axis is often dysregulated in digestive system tumors impacting critical cellular processes. Abnormal expression of specific Wnt-related lncRNAs such as LINC01606 (promotes motility), SLCO4A1-AS1 (promotes motility), and SH3BP5-AS1 (induces chemoresistance), plays a crucial role in these malignancies. These lncRNAs are promising targets for cancer diagnosis and therapy, offering new treatment perspectives. The lncRNAs, NEF and GASL1, differentially expressed in plasma show diagnostic potential for esophageal squamous cell carcinoma and gastric cancer, respectively. Additionally, Wnt pathway inhibitors like XAV-939 have demonstrated preclinical efficacy, underscoring their therapeutic potential. This review comprehensively analyzes the lncRNA/Wnt axis, highlighting its impact on cell proliferation, motility, and chemoresistance. By elucidating the complex molecular mechanisms of the lncRNA/Wnt axis, we aim to identify potential therapeutic targets for digestive system tumors to pave the way for the development of targeted treatment strategies.

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lncRNA/Wnt信号通路在消化系统癌症中的作用：文献综述。

长非编码 RNA（lncRNA）/无翼鸟（Wnt）轴在消化系统肿瘤中经常失调，影响关键的细胞过程。与 Wnt 相关的特定 lncRNA（如 LINC01606（促进运动）、SLCO4A1-AS1（促进运动）和 SH3BP5-AS1（诱导化疗抗性））的异常表达在这些恶性肿瘤中起着至关重要的作用。这些lncRNA是癌症诊断和治疗的有望靶点，提供了新的治疗前景。血浆中差异表达的 lncRNA NEF 和 GASL1 分别显示了食管鳞癌和胃癌的诊断潜力。此外，XAV-939 等 Wnt 通路抑制剂已显示出临床前疗效，彰显了其治疗潜力。本综述全面分析了lncRNA/Wnt轴，强调了它对细胞增殖、运动和化疗耐药性的影响。通过阐明lncRNA/Wnt轴的复杂分子机制，我们旨在确定消化系统肿瘤的潜在治疗靶点，为开发靶向治疗策略铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464