Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb.

IF 4 3区 医学 Q2 CELL BIOLOGY
Disease Models & Mechanisms Pub Date : 2024-09-01 Epub Date: 2024-09-27 DOI:10.1242/dmm.050743
Julia Kramer, Rita Aires, Sean D Keeley, Tom Alexander Schröder, Günter Lauer, Tatiana Sandoval-Guzmán
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引用次数: 0

Abstract

The mandible plays an essential part in human life and, thus, defects in this structure can dramatically impair the quality of life in patients. Axolotls, unlike humans, are capable of regenerating their lower jaws; however, the underlying mechanisms and their similarities to those in limb regeneration are unknown. In this work, we used morphological, histological and transcriptomic approaches to analyze the regeneration of lateral resection defects in the axolotl mandible. We found that this structure can regenerate all missing tissues in 90 days through gap minimization, blastema formation and, finally, tissue growth, differentiation and integration. Moreover, transcriptomic comparisons of regenerating mandibles and limbs showed that they share molecular phases of regeneration, that these similarities peak during blastema stages and that mandible regeneration occurs at a slower pace. Altogether, our study demonstrates the existence of a shared regenerative program used in two different regenerating body structures with different embryonic origins in the axolotl and contributes to our understanding of the minimum requirements for a successful regeneration in vertebrates, bringing us closer to understand similar lesions in human mandibles.

Axolotl 下颌骨的再生是通过机械缝隙闭合和与肢体共享再生程序实现的。
下颌骨在人类生活中起着至关重要的作用,因此,这一结构的缺陷会严重影响患者的生活质量。与人类不同,轴龙能够再生其下颌骨,但其基本机制及其与肢体再生机制的相似性尚不清楚。在这项工作中,我们采用形态学、组织学和转录组学方法分析了斧腹鱼下颌骨侧面切除缺损的再生过程。我们发现,这种结构可以在90天内通过间隙最小化、胚芽组织形成以及最后的组织生长、分化和整合再生所有缺失组织。此外,对再生下颚和四肢的转录组比较表明,它们具有相同的再生分子阶段,这些相似性在胚泡阶段达到顶峰,而下颚的再生速度较慢。总之,我们的研究证明,在斧尾蜥胚胎起源不同的两种不同再生身体结构中,存在一个共享的再生程序,有助于我们理解脊椎动物成功再生的最低要求,使我们更接近于理解人类下颌骨的类似病变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Disease Models & Mechanisms
Disease Models & Mechanisms 医学-病理学
CiteScore
6.60
自引率
7.00%
发文量
203
审稿时长
6-12 weeks
期刊介绍: Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
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