Acute Pulmonary Embolism: Evidence, Innovation, and Horizons.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reports Pub Date : 2024-11-01 Epub Date: 2024-08-31 DOI:10.1007/s11886-024-02128-0

Stanislav Henkin, Francisco Ujueta, Alyssa Sato, Gregory Piazza

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Abstract

Purpose of review: Pulmonary embolism (PE) is the third most common cause of cardiovascular morbidity and mortality. The goal of this review is to discuss the most up-to-date literature on epidemiology, diagnosis, risk stratification, and management of acute PE.

Recent findings: Despite an increase in annual incidence rate of PE in the United States and development of multiple advanced therapies for treatment of acute PE, PE-related mortality is not consistently decreasing across populations. Although multiple risk stratification schemes have been developed, it is still unclear which advanced therapy should be used for the individual patient and optimal timing. Fortunately, multiple randomized clinical trials are underway to answer these questions. Nevertheless, up to 50% of patients have persistent reduced quality of life 6 months after acute PE, termed post-PE syndrome. Despite advances in therapeutic options for management of acute PE, many questions remain unanswered, including optimal risk stratification and management of acute PE.

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急性肺栓塞：证据、创新和前景。

审查目的：肺栓塞（PE）是心血管疾病发病率和死亡率的第三大常见原因。本综述旨在讨论有关急性肺栓塞的流行病学、诊断、风险分层和管理的最新文献：最近的研究结果：尽管美国 PE 的年发病率有所上升，并开发出多种先进疗法来治疗急性 PE，但与 PE 相关的死亡率并没有在不同人群中持续下降。尽管已开发出多种风险分层方案，但目前仍不清楚患者应采用哪种先进疗法以及最佳治疗时机。幸运的是，目前正在进行多项随机临床试验来回答这些问题。尽管如此，仍有多达 50% 的患者在急性 PE 发生 6 个月后生活质量持续下降，这被称为 PE 后综合征。尽管急性 PE 的治疗方案取得了进展，但许多问题仍未得到解答，包括急性 PE 的最佳风险分层和管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.