Tofacitinib for Pityriasis Rubra Pilaris: A Case Report.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S470170

Hongyan Tan, Bin Zhang, Xiawei Kang, Lvyao Wang, Xiao Qiu, Xiangyu Hu

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引用次数: 0

Abstract

Purpose: At present, we have entered the era of using biological agents and small molecule targeted drugs to treat diseases. Although there have been many reports of biological agents treating pityriasis rubra pilaris recently, the clinical application of the JAK inhibitors in the treatment of pityriasis rubra pilaris has been rarely reported, and there is a lack of evidence on the safety and efficacy of these drugs. We explore the use of the JAK inhibitor tofacitinib in the treatment of pityriasis rubra pilaris with significant efficacy and no significant side effects, providing new ideas for the clinical treatment of pityriasis rubra pilaris.

Methods: We cover a case of pityriasis rubra pilaris treated with the JAK inhibitor tofacitinib, which showed significant efficacy without any adverse effects.

Results: This case report showed that the JAK inhibitor tofacitinib had significant clinical efficacy in the treatment of pityriasis rubra pilaris. We speculated that the treatment of pityriasis rubra pilaris with the JAK inhibitors may be related to blocking the activation of the JAK/STAT pathway, thereby blocking the high expression of cytokines IL-17, IL-12/IL-23, IL-23, TNF-α.

Conclusion: The JAK inhibitor tofacitinib can become a new option for treating pityriasis rubra pilaris.

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托法替尼治疗红斑狼疮：病例报告。

目的：目前，我们已经进入了使用生物制剂和小分子靶向药物治疗疾病的时代。虽然近来关于生物制剂治疗红斑狼疮的报道很多，但临床上应用JAK抑制剂治疗红斑狼疮的报道却很少，其安全性和有效性也缺乏证据。我们探讨了JAK抑制剂托法替尼用于治疗红斑性脓疱病，疗效显著且无明显副作用，为红斑性脓疱病的临床治疗提供了新思路：方法：我们报道了一例使用JAK抑制剂托法替尼治疗红斑性脓疱病的病例，其疗效显著，且无任何不良反应：结果：本病例报告显示，JAK抑制剂托法替尼治疗红斑性脓疱病具有显著的临床疗效。我们推测，JAK抑制剂治疗红斑狼疮可能与阻断JAK/STAT通路的激活有关，从而阻断细胞因子IL-17、IL-12/IL-23、IL-23、TNF-α的高表达：结论：JAK抑制剂托法替尼可以成为治疗丝状红斑的新选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.