The Causal Relationship Between Physical Activity and Skin Cancer Risk: An Univariable Mendelian Randomization Study.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S472443

Xiaoming Fu, Fuhai Zeng, Linling Li, Guoquan Liu, Qing Zhong, Shouwan Chen

{"title":"The Causal Relationship Between Physical Activity and Skin Cancer Risk: An Univariable Mendelian Randomization Study.","authors":"Xiaoming Fu, Fuhai Zeng, Linling Li, Guoquan Liu, Qing Zhong, Shouwan Chen","doi":"10.2147/CCID.S472443","DOIUrl":null,"url":null,"abstract":"Background: The existing observational research on the relationship between physical activity (PA) and skin cancer (SC) is contentious, which points to the intricate nature of their association and underscores the imperative for more nuanced research to untangle the causal dynamics at play. The aim of this article is to delve deeper into this complex relationship, seeking to clarify whether PA serves as a protective factor against SC, or contributes to its risk.Methods: We utilized data from the genome-wide association study (GWAS) of PA from GWAS Catalog (include self-reported moderate to vigorous PA (MVPA), self-reported vigorous PA (VPA), and accelerometer-based average-accelerated PA). The data of SC is from FinnGen. All of the participants are of European ancestry. We used two-sample Mendelian Randomization (TSMR) to analyze the causal relationship between PA and SC.The research was conducted using inverse variance weighted (IVW) method as the primary approach, and MR Egger regression as supplementary analytical method. To ensure the robustness of the results, Cochran's Q-test and MR pleiotropy residual sum and outlier (MR-PRESSO) global tests were used to measure sensitivity.Results: Our analysis indicated that average-accelerated PA was associated with an increased risk of SC (ORIVW = 0.94, 95% CI 0.93-0.96, P < 0.001). While neither MVPA (ORIVW = 0.99, 95% CI 0.67-1.47, P = 0.962) nor VPA (ORIVW = 0.80, 95% CI 0.29-2.18, P = 0.656) shows causal relationship on risk of SC.Conclusion: Our research suggests that PA is associated with a decrease in SC, provides a new perspective for future SC prevention. Our research findings bolster the hypothesis that increased levels of PA, characterized by average acceleration, are associated with a reduced risk of developing skin cancer. This has filled the gap of research on the causal relationship between PA and SC, and could pave the way for novel preventive strategies against skin cancer.","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"1963-1972"},"PeriodicalIF":1.9000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366249/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical, Cosmetic and Investigational Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CCID.S472443","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The existing observational research on the relationship between physical activity (PA) and skin cancer (SC) is contentious, which points to the intricate nature of their association and underscores the imperative for more nuanced research to untangle the causal dynamics at play. The aim of this article is to delve deeper into this complex relationship, seeking to clarify whether PA serves as a protective factor against SC, or contributes to its risk.

Methods: We utilized data from the genome-wide association study (GWAS) of PA from GWAS Catalog (include self-reported moderate to vigorous PA (MVPA), self-reported vigorous PA (VPA), and accelerometer-based average-accelerated PA). The data of SC is from FinnGen. All of the participants are of European ancestry. We used two-sample Mendelian Randomization (TSMR) to analyze the causal relationship between PA and SC.The research was conducted using inverse variance weighted (IVW) method as the primary approach, and MR Egger regression as supplementary analytical method. To ensure the robustness of the results, Cochran's Q-test and MR pleiotropy residual sum and outlier (MR-PRESSO) global tests were used to measure sensitivity.

Results: Our analysis indicated that average-accelerated PA was associated with an increased risk of SC (OR_IVW = 0.94, 95% CI 0.93-0.96, P < 0.001). While neither MVPA (OR_IVW = 0.99, 95% CI 0.67-1.47, P = 0.962) nor VPA (OR_IVW = 0.80, 95% CI 0.29-2.18, P = 0.656) shows causal relationship on risk of SC.

Conclusion: Our research suggests that PA is associated with a decrease in SC, provides a new perspective for future SC prevention. Our research findings bolster the hypothesis that increased levels of PA, characterized by average acceleration, are associated with a reduced risk of developing skin cancer. This has filled the gap of research on the causal relationship between PA and SC, and could pave the way for novel preventive strategies against skin cancer.

查看原文本刊更多论文

体育锻炼与皮肤癌风险之间的因果关系：单变量孟德尔随机研究。

背景：关于体力活动（PA）与皮肤癌（SC）之间关系的现有观察性研究存在争议，这表明二者之间的关系错综复杂，并强调必须开展更细致的研究，以解开其中的因果关系。本文旨在深入探讨这一复杂的关系，试图阐明 PA 是皮肤癌的保护因素，还是导致皮肤癌风险的因素：我们利用了全基因组关联研究（GWAS）的数据，这些数据来自《GWAS 目录》（包括自我报告的中度至剧烈运动（MVPA）、自我报告的剧烈运动（VPA）和基于加速计的平均加速运动）。SC 数据来自 FinnGen，所有参与者均为欧洲血统。我们采用双样本孟德尔随机法（TSMR）分析 PA 与 SC 之间的因果关系。研究以反向方差加权法（IVW）为主要方法，MR Egger 回归为辅助分析方法。为确保研究结果的稳健性，我们使用了 Cochran's Q 检验和 MR pleiotropy residual sum and outlier (MR-PRESSO) 全局检验来衡量敏感性：我们的分析表明，平均加速 PA 与 SC 风险增加相关（ORIVW = 0.94，95% CI 0.93-0.96，P IVW = 0.99，95% CI 0.67-1.47，P = 0.962），VPA（ORIVW = 0.80，95% CI 0.29-2.18，P = 0.656）也与 SC 风险无因果关系：我们的研究表明，PA 与 SC 的减少有关，为今后预防 SC 提供了新的视角。我们的研究结果支持了这样的假设：以平均加速度为特征的 PA 水平的提高与皮肤癌发病风险的降低有关。这填补了 PA 与 SC 之间因果关系研究的空白，并为新型皮肤癌预防策略铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.