Impact of Herpes Zoster and Postherpetic Neuralgia on the Quality of Life in China: A Prospective Study.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S471823

Yong Liu, Hui Liu, Queqiao Bian, Shuhuan Zhang, Yanmin Guan

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Abstract

Background: Herpes zoster (HZ) and postherpetic neuralgia (PHN) significantly affect patients' quality of life (QoL). Cultural differences may lead to different patient-reported outcomes across countries. The current study aims to evaluate the detrimental impact of HZ and PHN on QoL in China.

Methods: This prospective study was conducted from January 2020 to April 2023. We used the Zoster Brief Pain Inventory (ZBPI) and 5-level EuroQol-5 Dimension (EQ-5D-5L) questionnaire to assess the QoL of HZ and PHN patients. Patients were required to complete the questionnaires at 15, 30, 60, and 90 days after the onset of the HZ rash. Additional questionnaires were administered at 120, 150, and 180 days for those who developed PHN within three months of the rash's onset.

Results: A cohort of 633 patients with a median age of 63 years were included in the study. The mean delay from the appearance of the initial HZ rash to the first medical consultation was 5.1 ± 2.8 days. Approximately 30% of the HZ patients (189/633) went on to develop PHN. For patients with HZ who did not progress to PHN, the ZBPI worst pain score and impaired QoL had nearly resolved by day 90 post-rash onset. Conversely, there was no significant improvement in the ZBPI worst pain score and QoL for those with PHN, even by day 180 post-rash onset.

Conclusion: Both HZ and PHN significantly impaired patients' QoL. However, the impairment caused by PHN was more severe in both intensity and duration.

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带状疱疹和带状疱疹后神经痛对中国人生活质量的影响：前瞻性研究。

背景：带状疱疹（HZ）和带状疱疹后遗神经痛（PHN）严重影响患者的生活质量（QoL）。文化差异可能导致各国患者报告的结果不同。本研究旨在评估中国 HZ 和 PHN 对 QoL 的不利影响：本前瞻性研究于 2020 年 1 月至 2023 年 4 月进行。我们使用带状疱疹简易疼痛量表（ZBPI）和欧洲质量五级问卷（EQ-5D-5L）来评估HZ和PHN患者的QoL。患者需在 HZ 皮疹出现后 15、30、60 和 90 天完成问卷调查。对于在皮疹发生后三个月内出现 PHN 的患者，在 120 天、150 天和 180 天时再进行一次问卷调查：研究共纳入了 633 名患者，中位年龄为 63 岁。从最初出现 HZ 皮疹到首次就诊的平均延迟时间为 5.1±2.8 天。约30%的HZ患者（189/633）随后发展为PHN。对于未发展为 PHN 的 HZ 患者，其 ZBPI 最严重疼痛评分和 QoL 受损情况在皮疹发生后第 90 天基本消失。相反，即使到皮疹发生后第180天，PHN患者的ZBPI最严重疼痛评分和QoL也没有明显改善：结论：HZ 和 PHN 都会严重损害患者的 QoL。结论：HZ 和 PHN 都会严重损害患者的 QoL，但 PHN 造成的损害在强度和持续时间上都更为严重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.