TESC associated with poor prognosis enhances cancer stemness and migratory properties in liver cancer.

IF 3.2 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Experimental Medicine Pub Date : 2024-08-29 DOI:10.1007/s10238-024-01469-y

Peng Ye, Shahang Luo, Junyu Huang, Xihua Fu, Xiaoxia Chi, Jong-Ho Cha, Yumei Chen, Yanjun Mai, Kai-Wen Hsu, Xiuwen Yan, Wen-Hao Yang

{"title":"TESC associated with poor prognosis enhances cancer stemness and migratory properties in liver cancer.","authors":"Peng Ye, Shahang Luo, Junyu Huang, Xihua Fu, Xiaoxia Chi, Jong-Ho Cha, Yumei Chen, Yanjun Mai, Kai-Wen Hsu, Xiuwen Yan, Wen-Hao Yang","doi":"10.1007/s10238-024-01469-y","DOIUrl":null,"url":null,"abstract":"<p><p>Liver cancer stem cells (LCSCs) are responsible for recurrence, metastasis, and drug resistance in liver cancer. However, the genes responsible for inducing LCSCs have not been fully identified. Based on our previous study, we found that tescalcin (TESC), a calcium-binding EF hand protein that plays a crucial role in chromatin remodeling, transcriptional regulation, and epigenetic modifications, was up-regulated in LCSCs of spheroid cultures. By searching the Cancer Genome Atlas, International Cancer Genome Consortium, Human Protein Atlas, and Kaplan-Meier Plotter databases, we found that TESC expression was significantly elevated in liver cancer compared with that in normal liver tissue and was predictive of a decreased overall survival rate. Multivariate Cox analysis revealed TESC to be an independent prognostic factor for survival. High TESC expression was positively associated with cancer stem cell pathways, cancer stem cell surface markers, stemness transcription factors, epithelial-mesenchymal transition (EMT) factors, immune checkpoint proteins, and various cancer-related biological processes in liver cancer. Furthermore, TESC was implicated as promoting cancer stem cell properties through its influence on EMT. We demonstrated that TESC is a novel stemness-related gene that can serve as an independent prognostic factor for liver cancer.</p>","PeriodicalId":10337,"journal":{"name":"Clinical and Experimental Medicine","volume":"24 1","pages":"206"},"PeriodicalIF":3.2000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362204/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10238-024-01469-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

Liver cancer stem cells (LCSCs) are responsible for recurrence, metastasis, and drug resistance in liver cancer. However, the genes responsible for inducing LCSCs have not been fully identified. Based on our previous study, we found that tescalcin (TESC), a calcium-binding EF hand protein that plays a crucial role in chromatin remodeling, transcriptional regulation, and epigenetic modifications, was up-regulated in LCSCs of spheroid cultures. By searching the Cancer Genome Atlas, International Cancer Genome Consortium, Human Protein Atlas, and Kaplan-Meier Plotter databases, we found that TESC expression was significantly elevated in liver cancer compared with that in normal liver tissue and was predictive of a decreased overall survival rate. Multivariate Cox analysis revealed TESC to be an independent prognostic factor for survival. High TESC expression was positively associated with cancer stem cell pathways, cancer stem cell surface markers, stemness transcription factors, epithelial-mesenchymal transition (EMT) factors, immune checkpoint proteins, and various cancer-related biological processes in liver cancer. Furthermore, TESC was implicated as promoting cancer stem cell properties through its influence on EMT. We demonstrated that TESC is a novel stemness-related gene that can serve as an independent prognostic factor for liver cancer.

Abstract Image

查看原文本刊更多论文

与预后不良有关的 TESC 可增强肝癌的癌症干性和迁移特性。

肝癌干细胞（LCSCs）是肝癌复发、转移和耐药性的罪魁祸首。然而，诱导肝癌干细胞的基因尚未完全确定。在之前研究的基础上，我们发现钙结合EF手蛋白Tescalcin（TESC）在球形培养的LCSCs中上调，TESC是一种钙结合EF手蛋白，在染色质重塑、转录调控和表观遗传修饰中发挥重要作用。通过检索癌症基因组图谱、国际癌症基因组联盟、人类蛋白质图谱和 Kaplan-Meier Plotter 数据库，我们发现与正常肝组织相比，TESC 在肝癌中的表达显著升高，并可预测总生存率的下降。多变量 Cox 分析显示，TESC 是影响生存率的独立预后因素。TESC的高表达与肝癌中的癌症干细胞通路、癌症干细胞表面标记物、干性转录因子、上皮-间质转化（EMT）因子、免疫检查点蛋白以及各种癌症相关生物过程呈正相关。此外，TESC还被认为通过影响EMT促进了癌症干细胞的特性。我们证明了TESC是一种新型干细胞相关基因，可作为肝癌的独立预后因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical and Experimental Medicine 医学-医学：研究与实验

CiteScore

4.80

自引率

2.20%

发文量

159

审稿时长

2.5 months

期刊介绍： Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.