{"title":"The transcription regulator ID3 maintains tumor-specific memory CD8<sup>+</sup> T cells in draining lymph nodes during tumorigenesis.","authors":"Ling Ran, Zhengliang Yue, Mengqu Ran, Qiao Liu, Xingxing Su, Lisha Wang, Shuqiong Wen, Luming Xu, Shun Lei, Zhanpeng Ou, Jianjun Hu, Yan Zhang, Chenxi Qin, Yuzhu Wang, Qinyi He, Yezi Chen, Wen Liu, Lilin Ye, Qizhao Huang, Lifan Xu","doi":"10.1016/j.celrep.2024.114690","DOIUrl":null,"url":null,"abstract":"<p><p>During tumorigenesis, the recently identified tumor-specific memory T cells in draining lymph nodes (TdLN-T<sub>TSM</sub> cells) play a pivotal role in tumor repression that gives rise to progenitor exhausted T (T<sub>PEX</sub>) cells and further replenishes tumor-specific CD8<sup>+</sup> T cells residing in the tumor microenvironment (TME). However, how T<sub>TSM</sub> cells are maintained in TdLN is largely unknown. Here, we show that the transcription regulator ID3 (inhibitor of DNA binding 3) is highly expressed by T<sub>TSM</sub> cells compared with other CD8<sup>+</sup> T cell subsets. The deficiency of ID3 significantly interrupts the maintenance of T<sub>TSM</sub> and T<sub>PEX</sub> cells, resulting in decreased tumor-infiltrating CD8<sup>+</sup> T cells and impaired tumor control. Consistent with this, overexpression of ID3 in CD8<sup>+</sup> T cells increases the T<sub>TSM</sub> cell population and enhances the anti-tumor immune response.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":null,"pages":null},"PeriodicalIF":7.5000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell reports","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.celrep.2024.114690","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
During tumorigenesis, the recently identified tumor-specific memory T cells in draining lymph nodes (TdLN-TTSM cells) play a pivotal role in tumor repression that gives rise to progenitor exhausted T (TPEX) cells and further replenishes tumor-specific CD8+ T cells residing in the tumor microenvironment (TME). However, how TTSM cells are maintained in TdLN is largely unknown. Here, we show that the transcription regulator ID3 (inhibitor of DNA binding 3) is highly expressed by TTSM cells compared with other CD8+ T cell subsets. The deficiency of ID3 significantly interrupts the maintenance of TTSM and TPEX cells, resulting in decreased tumor-infiltrating CD8+ T cells and impaired tumor control. Consistent with this, overexpression of ID3 in CD8+ T cells increases the TTSM cell population and enhances the anti-tumor immune response.
期刊介绍:
Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted.
The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership.
The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.