Body mass index and the prevalence of high-risk colorectal adenomas in a population undergoing screening colonoscopy in Alberta, Canada.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Causes & Control Pub Date : 2024-12-01 Epub Date: 2024-08-30 DOI:10.1007/s10552-024-01914-z

John M Hutchinson, Joshua Chow, Eliya Farah, Matthew T Warkentin, Yibing Ruan, Robert J Hilsden, Darren R Brenner

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Abstract

Purpose: There is limited evidence regarding body mass index (BMI) as an early marker of high-risk adenoma (HRA) at the time of screening colonoscopy. Because high-risk adenomas (HRA) can develop into colorectal cancer (CRC), BMI could serve as an important clinical predictor of future risk of CRC.

Methods: We examined data from 1831 adults undergoing screening colonoscopy at the Forzani & MacPhail Colon Cancer Screening Center in Alberta, Canada. We fit multivariable logistic regression models to examine the association between BMI and HRA. Non-linear relationships for BMI on HRA were also evaluated using restricted cubic splines.

Results: The mean BMI in patients with HRA was 28.2 kg/m² compared to 27.4 kg/m² in patients without adenomas (t test: p = 0.003). In the adjusted models, those with a BMI over 30 kg/m² had 1.45 (95% CI 1.05-2.00) times the odds of HRA detected during colonoscopy compared to those with a BMI below 25 kg/m². Examining BMI as continuous, the odds of HRA were 1.20 (95% CI 1.04-1.37) times higher for every 5 kg/m² increase in BMI.

Conclusion: The findings of this study suggest that excess body mass is associated with higher risk of HRA among a screening population and may be useful an early marker of future disease.

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加拿大艾伯塔省接受结肠镜筛查人群的体重指数和高危结肠直肠腺瘤发病率。

目的：关于在进行结肠镜筛查时将体重指数（BMI）作为高危腺瘤（HRA）的早期标志物的证据有限。由于高危腺瘤（HRA）可发展为结直肠癌（CRC），因此体重指数可作为未来患 CRC 风险的重要临床预测指标：我们研究了在加拿大阿尔伯塔省 Forzani & MacPhail 结肠癌筛查中心接受结肠镜筛查的 1831 名成人的数据。我们建立了多变量逻辑回归模型来研究体重指数与 HRA 之间的关系。我们还使用限制性三次样条对 BMI 与 HRA 的非线性关系进行了评估：HRA 患者的平均体重指数为 28.2 kg/m2，而无腺瘤患者的平均体重指数为 27.4 kg/m2（t 检验：P = 0.003）。在调整模型中，与 BMI 低于 25 kg/m2 的患者相比，BMI 超过 30 kg/m2 的患者在结肠镜检查中发现 HRA 的几率是后者的 1.45 倍（95% CI 1.05-2.00）。如果将 BMI 作为连续指标进行研究，BMI 每增加 5 kg/m2 ，HRA 的几率就增加 1.20 倍（95% CI 1.04-1.37）：本研究结果表明，在筛查人群中，体重超标与较高的 HRA 风险有关，可能是未来疾病的早期标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生

CiteScore

3.90

自引率

4.30%

发文量

130

审稿时长

6.6 months

期刊介绍： Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.