Antimicrobial resistance in Klebsiella pneumoniae: an overview of common mechanisms and a current Canadian perspective.

IF 1.8 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Canadian journal of microbiology Pub Date : 2024-12-01 Epub Date: 2024-08-30 DOI:10.1139/cjm-2024-0032

Hannah G Braun, Sumudu R Perera, Yannick Dn Tremblay, Jenny-Lee Thomassin

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引用次数: 0

Abstract

Klebsiella pneumoniae is a ubiquitous opportunistic pathogen of the family Enterobacteriaceae. K. pneumoniae is a member of the ESKAPEE pathogens (Enterococcus faecium, Staphylococcus aureus, K. pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., and Escherichia coli), a group of bacteria that cause nosocomial infections and are able to resist killing by commonly relied upon antimicrobial agents. The acquisition of antimicrobial resistance (AMR) genes is increasing among community and clinical isolates of K. pneumoniae, making K. pneumoniae a rising threat to human health. In addition to the increase in AMR, K. pneumoniae is also thought to disseminate AMR genes to other bacterial species. In this review, the known mechanisms of K. pneumoniae AMR will be described and the current state of AMR K. pneumoniae within Canada will be discussed, including the impact of the coronavirus disease-2019 pandemic, current perspectives, and outlook for the future.

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肺炎克雷伯氏菌的抗菌药耐药性：常见机制概述和当前加拿大的观点。

肺炎克雷伯菌是肠杆菌科中一种无处不在的机会性病原体。肺炎克雷伯菌是 ESKAPEE 病原体（粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌、肠杆菌属和大肠埃希菌）中的一员，ESKAPEE 是一组可引起医院内感染的细菌，能够抵抗常用抗菌药物的杀灭。在社区和临床分离的肺炎双球菌中，获得抗菌药耐药性（AMR）基因的情况越来越多，使肺炎双球菌对人类健康的威胁日益严重。除了 AMR 的增加，肺炎克氏菌还被认为会将 AMR 基因传播给其他细菌物种。在本综述中，将介绍已知的肺炎克雷伯菌 AMR 机制，并讨论加拿大肺炎克雷伯菌 AMR 的现状，包括 COVID-19 大流行的影响、当前观点和未来展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian journal of microbiology 生物-免疫学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

2.5 months

期刊介绍： Published since 1954, the Canadian Journal of Microbiology is a monthly journal that contains new research in the field of microbiology, including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.