Serum follistatin like 1 in children with obesity and metabolic-associated fatty liver disease.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2024-08-29 DOI:10.1186/s12902-024-01702-5

Lujie Liu, Meng Li, Yujie Qin, Luyang Liu, Yanfeng Xiao

{"title":"Serum follistatin like 1 in children with obesity and metabolic-associated fatty liver disease.","authors":"Lujie Liu, Meng Li, Yujie Qin, Luyang Liu, Yanfeng Xiao","doi":"10.1186/s12902-024-01702-5","DOIUrl":null,"url":null,"abstract":"Background: Follistatin-like protein 1 (FSTL1) has been identified as a secreted glycoprotein that plays an important role in obesity. However, its role in children with metabolic-associated fatty liver disease (MAFLD) has not been investigated. This study aimed at characterizing the relationship between serum FSTL1 concentration and MAFLD in children with obesity.Methods: A total of 121 subjects were recruited from the Second Affiliated Hospital of Xi'an Jiaotong University, including 45 obese children with MAFLD, 31 obese children without MAFLD, and 45 healthy controls. Anthropometric parameters, biochemical data were measured and circulating FSTL1 levels were detected by ELISA.Results: The levels of FSTL1 in obese children with MAFLD were higher than that in obese children without MAFLD: 1.31 (0.35-2.29) ng/mL vs. 0.55 (0.36-1.38) ng/mL. Correlation analysis illustrated that FSTL1 was associated with nonesterified free fatty acid and leptin (r = 0.278, P < 0.05 and r = 0.572, P < 0.05, respectively). Binary logistic regression suggested that increased FSTL1 was a risk factor for MAFLD in children (OR = 1.105, 95% CI: 1.066-1.269, P < 0.05).Conclusions: Serum FSTL1 concentrations increase in obese children with MAFLD and may have the potential to be a risk factor for MAFLD in children with obesity.","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"165"},"PeriodicalIF":2.8000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11360849/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Endocrine Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12902-024-01702-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Follistatin-like protein 1 (FSTL1) has been identified as a secreted glycoprotein that plays an important role in obesity. However, its role in children with metabolic-associated fatty liver disease (MAFLD) has not been investigated. This study aimed at characterizing the relationship between serum FSTL1 concentration and MAFLD in children with obesity.

Methods: A total of 121 subjects were recruited from the Second Affiliated Hospital of Xi'an Jiaotong University, including 45 obese children with MAFLD, 31 obese children without MAFLD, and 45 healthy controls. Anthropometric parameters, biochemical data were measured and circulating FSTL1 levels were detected by ELISA.

Results: The levels of FSTL1 in obese children with MAFLD were higher than that in obese children without MAFLD: 1.31 (0.35-2.29) ng/mL vs. 0.55 (0.36-1.38) ng/mL. Correlation analysis illustrated that FSTL1 was associated with nonesterified free fatty acid and leptin (r = 0.278, P < 0.05 and r = 0.572, P < 0.05, respectively). Binary logistic regression suggested that increased FSTL1 was a risk factor for MAFLD in children (OR = 1.105, 95% CI: 1.066-1.269, P < 0.05).

Conclusions: Serum FSTL1 concentrations increase in obese children with MAFLD and may have the potential to be a risk factor for MAFLD in children with obesity.

查看原文本刊更多论文

肥胖症和代谢相关性脂肪肝患儿血清中的类绒毛膜促性腺激素 1。

背景：Follistatin-like protein 1（FSTL1）已被确认为一种分泌性糖蛋白，在肥胖症中发挥着重要作用。然而，它在代谢相关性脂肪肝（MAFLD）患儿中的作用尚未得到研究。本研究旨在描述肥胖症儿童血清 FSTL1 浓度与 MAFLD 之间的关系：方法：研究人员从西安交通大学第二附属医院招募了121名受试者，包括45名患有MAFLD的肥胖儿童、31名未患有MAFLD的肥胖儿童和45名健康对照组。研究人员测量了这些儿童的人体测量指标和生化数据，并用ELISA方法检测了循环中FSTL1的水平：结果：患有MAFLD的肥胖儿童的FSTL1水平高于未患有MAFLD的肥胖儿童：1.31（0.35-2.29）纳克/毫升 vs. 0.55（0.36-1.38）纳克/毫升。相关性分析表明，FSTL1 与非酯化游离脂肪酸和瘦素相关（r = 0.278，P 结论：FSTL1 与瘦素的相关性较低：患有MAFLD的肥胖儿童血清中的FSTL1浓度升高，有可能成为肥胖儿童MAFLD的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.