Microfluidic mixing by magnetic particles: Progress and prospects.

IF 2.6 4区 工程技术 Q2 BIOCHEMICAL RESEARCH METHODS
Biomicrofluidics Pub Date : 2024-08-23 eCollection Date: 2024-07-01 DOI:10.1063/5.0211204
I Misra, V Kumaran
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引用次数: 0

Abstract

Microfluidic systems have enormous potential for enabling point-of-care diagnostics due to a number of advantages, such as low sample volumes, small footprint, low energy requirements, uncomplicated setup, high surface-to-volume ratios, cost-effectiveness, etc. However, fluid mixing operations are constrained by molecular diffusion since the flow is usually in the laminar regime. The slow nature of molecular diffusion is a technological barrier to implementing fluid transformations in a reasonable time. In this context, magnetically actuated micro-mixers of different sizes, shapes, materials, and actuation techniques provide a way to enhance fluid mixing in microfluidic devices. In this paper, we review the currently existing micro-mixing technologies. From a fundamental perspective, the different magnetization models for permanent and induced dipoles are discussed. The single-particle dynamics in steady and oscillating magnetic fields is studied in order to determine the flow generated and the torque exerted on the fluid due to the magnetic particles. The effect of particle interactions, both magnetic and hydrodynamic, is examined.

磁性颗粒的微流体混合:进展与前景。
微流控系统具有样品量少、占地面积小、能耗低、设置简单、表面体积比高、成本效益高等优点,因此在实现床旁诊断方面具有巨大潜力。然而,流体混合操作受到分子扩散的限制,因为流动通常处于层流状态。分子扩散的缓慢特性是在合理时间内实现流体转换的技术障碍。在这种情况下,不同尺寸、形状、材料和致动技术的磁致动微型搅拌器为加强微流体设备中的流体混合提供了一种方法。在本文中,我们回顾了现有的微混合技术。从基础角度出发,讨论了永久偶极子和感应偶极子的不同磁化模型。研究了稳定磁场和振荡磁场中的单粒子动力学,以确定磁性粒子产生的流动和对流体施加的扭矩。研究了磁性和流体动力两方面粒子相互作用的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomicrofluidics
Biomicrofluidics 生物-纳米科技
CiteScore
5.80
自引率
3.10%
发文量
68
审稿时长
1.3 months
期刊介绍: Biomicrofluidics (BMF) is an online-only journal published by AIP Publishing to rapidly disseminate research in fundamental physicochemical mechanisms associated with microfluidic and nanofluidic phenomena. BMF also publishes research in unique microfluidic and nanofluidic techniques for diagnostic, medical, biological, pharmaceutical, environmental, and chemical applications. BMF offers quick publication, multimedia capability, and worldwide circulation among academic, national, and industrial laboratories. With a primary focus on high-quality original research articles, BMF also organizes special sections that help explain and define specific challenges unique to the interdisciplinary field of biomicrofluidics. Microfluidic and nanofluidic actuation (electrokinetics, acoustofluidics, optofluidics, capillary) Liquid Biopsy (microRNA profiling, circulating tumor cell isolation, exosome isolation, circulating tumor DNA quantification) Cell sorting, manipulation, and transfection (di/electrophoresis, magnetic beads, optical traps, electroporation) Molecular Separation and Concentration (isotachophoresis, concentration polarization, di/electrophoresis, magnetic beads, nanoparticles) Cell culture and analysis(single cell assays, stimuli response, stem cell transfection) Genomic and proteomic analysis (rapid gene sequencing, DNA/protein/carbohydrate arrays) Biosensors (immuno-assay, nucleic acid fluorescent assay, colorimetric assay, enzyme amplification, plasmonic and Raman nano-reporter, molecular beacon, FRET, aptamer, nanopore, optical fibers) Biophysical transport and characterization (DNA, single protein, ion channel and membrane dynamics, cell motility and communication mechanisms, electrophysiology, patch clamping). Etc...
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