TO SHOw how we have been ENgaged in the APS FiELD (What we learned on APS collaborating with Professor Yehuda Shoenfeld)

IF 9.2 1区 医学 Q1 IMMUNOLOGY
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Abstract

The present review reports the history of our scientific collaboration with Professor Shoenfeld's group. The collaboration started at the end of the 80s and was mainly focused on studies on the pathogenetic mechanisms of the anti-phospholipid syndrome (APS). Following the initial collaborative studies on antibodies against endothelium in systemic autoimmune vasculitis, we were able to use a similar strategy in APS. This line of research has resulted in the characterization of beta 2 glycoprotein I (β2GPI)-dependent anti-phospholipid antibodies (aPL) as mechanisms capable of mediating an endothelial perturbation crucial for the pathogenesis of APS. Thanks to these studies, the collaboration has led to the characterization of the membrane receptors for β2GPI and the cellular signaling resulting from antibody binding. This mechanism has also been shown to mediate the aPL effect on other cell types involved in APS pathogenesis. Finally, the exchange of information made it possible to replicate and extend the setting of animal models of the syndrome, which proved to be valuable tools for understanding the pathogenesis of the syndrome. It has been a long story recently refueled by common studies on the similarity of pro-inflammatory and pro-coagulant endotheliopathy in APS and in COVID-19.

了解我们是如何参与 APS FiELD 的(我们与 Yehuda Shoenfeld 教授合作在 APS 上学到了什么)。
本报告回顾了我们与肖恩费尔德教授小组的科研合作历史。合作始于上世纪80年代末,主要集中在抗磷脂综合征(APS)的发病机制研究上。在对全身性自身免疫性血管炎的内皮细胞抗体进行初步合作研究后,我们能够在抗磷脂综合症中使用类似的策略。这项研究的结果是,β2糖蛋白Ⅰ(β2GPI)依赖性抗磷脂抗体(aPL)能够介导对APS发病机制至关重要的内皮干扰机制。通过这些研究,双方合作确定了β2GPI膜受体的特征以及抗体结合产生的细胞信号。这一机制还被证明可以介导 aPL 对参与 APS 发病机制的其他细胞类型的影响。最后,信息交流使得复制和扩展该综合征的动物模型成为可能,这些动物模型被证明是了解该综合征发病机制的宝贵工具。最近,关于 APS 和 COVID-19 中促进炎症和促进凝血的内皮病变相似性的共同研究为这个漫长的故事注入了新的活力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Autoimmunity reviews
Autoimmunity reviews 医学-免疫学
CiteScore
24.70
自引率
4.40%
发文量
164
审稿时长
21 days
期刊介绍: Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.
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