Multiomics: Functional Molecular Biomarkers of Micronutrients for Public Health Application.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS
Lindsay H Allen, Michael Fenech, Marcia A LeVatte, Keith P West, David S Wishart
{"title":"Multiomics: Functional Molecular Biomarkers of Micronutrients for Public Health Application.","authors":"Lindsay H Allen, Michael Fenech, Marcia A LeVatte, Keith P West, David S Wishart","doi":"10.1146/annurev-nutr-062322-022751","DOIUrl":null,"url":null,"abstract":"<p><p>Adequate micronutrient intake and status are global public health goals. Vitamin and mineral deficiencies are widespread and known to impair health and survival across the life stages. However, knowledge of molecular effects, metabolic pathways, biological responses to variation in micronutrient nutriture, and abilities to assess populations for micronutrient deficiencies and their pathology remain lacking. Rapidly evolving methodological capabilities in genomics, epigenomics, proteomics, and metabolomics offer unparalleled opportunities for the nutrition research community to link micronutrient exposure to cellular health; discover new, arguably essential micronutrients of microbial origin; and integrate methods of molecular biology, epidemiology, and intervention trials to develop novel approaches to assess and prevent micronutrient deficiencies in populations. In this review article, we offer new terminology to specify nutritional application of multiomic approaches and encourage collaboration across the basic to public health sciences to advance micronutrient deficiency prevention.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":"44 1","pages":"125-153"},"PeriodicalIF":12.6000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-nutr-062322-022751","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

Abstract

Adequate micronutrient intake and status are global public health goals. Vitamin and mineral deficiencies are widespread and known to impair health and survival across the life stages. However, knowledge of molecular effects, metabolic pathways, biological responses to variation in micronutrient nutriture, and abilities to assess populations for micronutrient deficiencies and their pathology remain lacking. Rapidly evolving methodological capabilities in genomics, epigenomics, proteomics, and metabolomics offer unparalleled opportunities for the nutrition research community to link micronutrient exposure to cellular health; discover new, arguably essential micronutrients of microbial origin; and integrate methods of molecular biology, epidemiology, and intervention trials to develop novel approaches to assess and prevent micronutrient deficiencies in populations. In this review article, we offer new terminology to specify nutritional application of multiomic approaches and encourage collaboration across the basic to public health sciences to advance micronutrient deficiency prevention.

多组学:应用于公共卫生的微量营养素功能性分子生物标记。
充足的微量营养素摄入量和状况是全球公共卫生的目标。众所周知,维生素和矿物质缺乏症普遍存在,会损害人一生中各个阶段的健康和生存。然而,人们对微量营养素营养成分的分子效应、代谢途径、生物反应以及评估人群微量营养素缺乏症及其病理学的能力仍然缺乏了解。基因组学、表观基因组学、蛋白质组学和代谢组学方法能力的迅速发展为营养研究界提供了无与伦比的机会,使他们能够将微量营养素暴露与细胞健康联系起来;发现新的、可以说是必需的微生物来源的微量营养素;整合分子生物学、流行病学和干预试验方法,开发新的方法来评估和预防人群中的微量营养素缺乏症。在这篇综述文章中,我们提供了新的术语来说明多组学方法在营养学上的应用,并鼓励从基础科学到公共卫生科学的合作,以推进微量营养素缺乏症的预防工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信