Validation of advanced hybrid SPECT/CT system using dynamic anthropomorphic cardiac phantom

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Elad Gelbart, Alexander Krakovich, Yigal Sherm, Gilad Rabin, Hagit Ratner, Mickey Scheinowitz, Ronen Goldkorn
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引用次数: 0

Abstract

Objective

Myocardial blood flow (MBF) assessment can provide incremental diagnostic and prognostic information and thus the validation of dynamic SPECT is of high importance. We recently developed a novel cardiac phantom for dynamic SPECT validation and compared its performance against the GE Discovery NM 530c. We now report its use for validation of a new hybrid SPECT/CT System featuring advanced cadmium zinc telluride (CZT) technology in a ring array detector design (StarGuide™, GE HealthCare).

Methods

Our recently developed cardiac phantom with injected technetium-99m radiotracer was used to create physiological time activity curves (TACs) for the left ventricular (LV) cavity and the myocardium. The TACs allow the calculation of uptake rate (K1) and MBF. The StarGuide system was used to acquire and process the TACs, and these were compared to the TACs produced by the phantom and its mathematical model. Fifteen (15) experiments with different doses representing various MBF values were conducted, and a standard statistic tool was applied for significance.

Results

The TACs produced by the StarGuide system had a significant correlation (p < 0.001) with the reference TACs generated by the phantom both for the LV (r = 0.94) and for the myocardium (r = 0.89). The calculated MBF difference between the system and the phantom was 0.14 ± 0.16 ml/min/g and the average relative absolute difference was 13.2 ± 8.1%. A coefficient of variance of ≤ 11% was observed for all MBF subranges. The regional uptake rate values were similar to the global one with a maximum difference of 5%.

Conclusions

Our newly developed dynamic cardiac phantom was used for validation of the dynamic hybrid SPECT/CT CZT-based system (StarGuide™, GE). The accuracy and precision of the system for assessing MBF values were high. The new StarGuide system can reliably perform dynamic SPECT acquisitions over a wide range of myocardial perfusion flow rates.

Abstract Image

利用动态拟人化心脏模型验证先进的混合 SPECT/CT 系统。
目的:心肌血流(MBF)评估可提供增量诊断和预后信息,因此动态 SPECT 的验证非常重要。我们最近开发了一种用于动态 SPECT 验证的新型心脏模型,并将其性能与 GE Discovery NM 530c 进行了比较。现在,我们将其用于新型混合 SPECT/CT 系统的验证,该系统采用先进的碲化镉锌(CZT)技术和环形阵列探测器设计(StarGuide™,GE HealthCare):我们最近开发的心脏模型注入了锝-99m 放射性示踪剂,用于创建左心室(LV)腔和心肌的生理时间活动曲线(TAC)。通过 TACs 可以计算摄取率 (K1) 和 MBF。StarGuide 系统用于获取和处理 TACs,并将其与模型及其数学模型生成的 TACs 进行比较。对代表不同 MBF 值的不同剂量进行了十五(15)次实验,并使用标准统计工具进行了显著性分析:结果:StarGuide 系统产生的 TACs 具有显著的相关性(p 结论:StarGuide 系统产生的 TACs 与数学模型产生的 TACs 具有显著的相关性:我们新开发的动态心脏模型用于验证基于动态混合 SPECT/CT CZT 的系统(StarGuide™,GE)。该系统评估 MBF 值的准确度和精确度都很高。新型 StarGuide 系统能在广泛的心肌灌注流速范围内可靠地进行动态 SPECT 采集。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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