Association between the incident hypertension duration and cognitive performance in older adults: data from the NHANES 2011–2014

IF 3.4 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Chunlei Liu, Qi Li, Zhuqing Li, Li Wang, Che Wang, Xiaoyu Du, Wenjuan Song, Xiaotong Sun, Chengzhi Lu
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引用次数: 0

Abstract

Background

Established evidences have demonstrated that hypertension was associated with the cognitive impairment. But the associations between the duration of hypertension exposure and cognitive performance are still inconclusive.

Objectives

The objective of this study was to assess the association between the duration of hypertension diagnosis and cognitive performance in older adults by the National Health and Nutrition Examination Survey (2011–2014).

Methods

To evaluate the relationship between the hypertension duration and cognitive performance, we conducted the logistic regression analysis. Furthermore, we also performed the Restricted cubic spline (RCS) analysis to assess the nonlinear relationship between the duration of exposure to hypertension and cognitive performance.

Results

Initially, total 19,931 participants were included in this study, and 2928 individuals were enrolled. With the increase of hypertension duration, more risk of cognitive impairment was observed in the Digit Symbol Substitution test (DSST) (OR = 1.012, 1.006–1.019), and a similar trend was observed in Animal Fluency test (AFT) (OR = 1.009,1.003–1.016). The RCS results showed that the hypertension duration pattern was linear associated with the risk of cognitive impairment in DDST (P for non–linearity = 0.758). Meanwhile, subgroups analysis of midlife hypertension, we revealed that linear association with the risk of cognitive impairment in DSST (P for non–linearity = 0.391) and CERAD (P for non–linearity = 0.849) among hypertension diagnose < 55 years populations.

Conclusion

Collectively, our finding indicates that longer duration of exposure to hypertension worsens the cognition performance, especially for middle-aged hypertension.

Abstract Image

老年人高血压发病持续时间与认知能力之间的关系:2011-2014 年国家健康调查(NHANES)数据。
背景:已有证据表明,高血压与认知障碍有关。但高血压暴露持续时间与认知能力之间的关系仍无定论:本研究旨在通过美国国家健康与营养调查(2011-2014 年)评估老年人高血压诊断持续时间与认知能力之间的关系:为了评估高血压病程与认知能力之间的关系,我们进行了逻辑回归分析。此外,我们还进行了限制立方样条线(RCS)分析,以评估高血压暴露持续时间与认知能力之间的非线性关系:本研究最初共纳入 19931 名参与者,其中 2928 人被纳入研究。随着高血压持续时间的延长,在数字符号替换测试(DSST)(OR = 1.012,1.006-1.019)和动物流畅性测试(AFT)(OR = 1.009,1.003-1.016)中观察到更多的认知障碍风险。RCS结果显示,高血压持续时间模式与DDST认知障碍风险呈线性相关(非线性P=0.758)。同时,在对中年高血压进行亚组分析时,我们发现在高血压诊断中,DSST(非线性P=0.391)和CERAD(非线性P=0.849)与认知障碍风险呈线性相关:总之,我们的研究结果表明,暴露于高血压的时间越长,认知能力越差,尤其是中年高血压患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.90
自引率
5.00%
发文量
283
审稿时长
1 months
期刊介绍: Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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