Metabolic Control of Microglia.

Q3 Neuroscience
Monica Emili Garcia-Segura, Stefano Pluchino, Luca Peruzzotti-Jametti
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引用次数: 0

Abstract

Microglia, immune sentinels of the central nervous system (CNS), play a critical role in maintaining its health and integrity. This chapter delves into the concept of immunometabolism, exploring how microglial metabolism shapes their diverse immune functions. It examines the impact of cell metabolism on microglia during various CNS states, including homeostasis, development, aging, and inflammation. Particularly in CNS inflammation, the chapter discusses how metabolic rewiring in microglia can initiate, resolve, or perpetuate inflammatory responses. The potential of targeting microglial metabolism as a therapeutic strategy for chronic CNS disorders with prominent innate immune cell activation is also explored.

小胶质细胞的代谢控制
小胶质细胞是中枢神经系统(CNS)的免疫哨兵,在维护中枢神经系统的健康和完整性方面发挥着至关重要的作用。本章深入探讨免疫代谢的概念,探讨小胶质细胞的新陈代谢如何塑造其各种免疫功能。它探讨了细胞代谢在中枢神经系统的各种状态下对小胶质细胞的影响,包括平衡、发育、衰老和炎症。特别是在中枢神经系统炎症中,本章讨论了小胶质细胞中的新陈代谢重新布线是如何启动、解决或延续炎症反应的。本章还探讨了以小胶质细胞代谢为靶点作为治疗策略的潜力,以治疗先天性免疫细胞活化突出的慢性中枢神经系统疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in neurobiology
Advances in neurobiology Neuroscience-Neurology
CiteScore
2.80
自引率
0.00%
发文量
0
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