Different aspects of immunological profile in patients with Non-Alcoholic Fatty liver disease.

IF 1.3 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Acta gastro-enterologica Belgica Pub Date : 2024-04-01 DOI:10.51821/87.2.12205

H A Osman, M Tag-Adeen, U M Abdelaal, E Elgezawy, K A Nasif, A Nafady

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引用次数: 0

Abstract

Background: NAFLD is thought to affect approximately one-fourth of the world's population. Therefore, we evaluated the role of serum complement and immunoglobulins in the NAFLD pathogenesis.

Patients and methods: 200 participants were used in this study, divided into two groups; Group I: 100 NAFLD patients and Group II: 100 healthy volunteers. The diagnosis of NAFLD is based on non-invasive methods, following the EASL guideline 2022. IgG, IgM, IgA, C3, and C4 assays were performed on all participants.

Results: When the immunological profiles of patients with NAFLD and healthy controls were compared, it was found that the mean IgA in NAFLD patients was (4.20±5.07), whereas the mean IgA in healthy controls was (2.22±1.05) (P=0.000). Additionally, a significant increase in IgG was found in NAFLD patients (17.08±3.87) compared with healthy controls (11.59±3.34), with a P value of (p<0.001). complement C3 and complement C4 levels significantly increased in nonalcoholic fatty liver disease patients (1.28± 0.61 and 0.40 ± 0.19, respectively), compared to healthy controls (0.90 ±0.27 and 0.30 ±0.12, respectively), with a significant P value (p<0.001 for each).

Conclusions: Elevated IgA, IgG, C3 and C4 exist in patients with NAFLD and could be associated with fatty liver development and progression of hepatic fibrosis in patients with NAFLD.

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非酒精性脂肪肝患者免疫特征的不同方面。

背景：非酒精性脂肪肝被认为影响着全球约四分之一的人口。因此，我们对血清补体和免疫球蛋白在非酒精性脂肪肝发病机制中的作用进行了评估。患者和方法：本研究有 200 名参与者，分为两组：第一组：100 名非酒精性脂肪肝患者；第二组：100 名健康志愿者。非酒精性脂肪肝的诊断基于非侵入性方法，遵循 EASL 指南 2022。对所有参与者进行了 IgG、IgM、IgA、C3 和 C4 检测：比较非酒精性脂肪肝患者和健康对照组的免疫学特征，发现非酒精性脂肪肝患者的平均 IgA 为（4.20±5.07），而健康对照组的平均 IgA 为（2.22±1.05）（P=0.000）。此外，与健康对照组（11.59±3.34）相比，非酒精性脂肪肝患者的 IgG（17.08±3.87）明显增加，P 值为（P结论：非酒精性脂肪肝患者的 IgA、IgG、C3 和 C4 升高，可能与非酒精性脂肪肝患者脂肪肝的发展和肝纤维化的进展有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta gastro-enterologica Belgica Medicine-Gastroenterology

CiteScore

2.30

自引率

20.00%

发文量

期刊介绍： The Journal Acta Gastro-Enterologica Belgica principally publishes peer-reviewed original manuscripts, reviews, letters to editors, book reviews and guidelines in the field of clinical Gastroenterology and Hepatology, including digestive oncology, digestive pathology, as well as nutrition. Pure animal or in vitro work will not be considered for publication in the Journal. Translational research papers (including sections of animal or in vitro work) are considered by the Journal if they have a clear relationship to or relevance for clinical hepato-gastroenterology (screening, disease mechanisms and/or new therapies). Case reports and clinical images will be accepted if they represent an important contribution to the description, the pathogenesis or the treatment of a specific gastroenterology or liver problem. The language of the Journal is English. Papers from any country will be considered for publication. Manuscripts submitted to the Journal should not have been published previously (in English or any other language), nor should they be under consideration for publication elsewhere. Unsolicited papers are peer-reviewed before it is decided whether they should be accepted, rejected, or returned for revision. Manuscripts that do not meet the presentation criteria (as indicated below) will be returned to the authors. Papers that go too far beyond the scope of the journal will be also returned to the authors by the editorial board generally within 2 weeks. The Journal reserves the right to edit the language of papers accepted for publication for clarity and correctness, and to make formal changes to ensure compliance with AGEB’s style. Authors have the opportunity to review such changes in the proofs.