Modulatory effects of miRNAs in doxorubicin resistance: A mechanistic view

IF 3.9 4区生物学 Q1 GENETICS & HEREDITY

Functional & Integrative Genomics Pub Date : 2024-09-02 DOI:10.1007/s10142-024-01431-x

Fatemeh Ebadi Meinag, Mina Fatahi, Vahid Vahedian, Nazila Fathi Maroufi, Bashir Mosayyebi, Elham Ahmadi, Mohammad Rahmati

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引用次数: 0

Abstract

MicroRNAs (miRNAs) are a group of small non-coding RNAs and play an important role in controlling vital biological processes, including cell cycle control, apoptosis, metabolism, and development and differentiation, which lead to various diseases such as neurological, metabolic disorders, and cancer. Chemotherapy consider as gold treatment approaches for cancer patients. However, chemotherapeutic is one of the main challenges in cancer management. Doxorubicin (DOX) is an anti-cancer drug that interferes with the growth and spread of cancer cells. DOX is used to treat various types of cancer, including breast, nervous tissue, bladder, stomach, ovary, thyroid, lung, bone, muscle, joint and soft tissue cancers. Also recently, miRNAs have been identified as master regulators of specific genes responsible for the mechanisms that initiate chemical resistance. miRNAs have a regulatory effect on chemotherapy resistance through the regulation of apoptosis process. Also, the effect of miRNAs p53 gene as a key tumor suppressor was confirmed via studies. miRNAs can affect main biological pathways include PI3K pathway. This review aimed to present the current understanding of the mechanisms and effects of miRNAs on apoptosis, p53 and PTEN/PI3K/Akt signaling pathway related to DOX resistance.

Graphical Abstract

miRNAs involve in DOX resistance according to effecting pathways.

Abstract Image

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miRNA 在多柔比星耐药性中的调节作用：从机理角度看

微小核糖核酸（miRNA）是一类小型非编码核糖核酸，在控制细胞周期控制、细胞凋亡、新陈代谢、发育和分化等重要生物过程中发挥着重要作用，而这些过程会导致神经系统、代谢紊乱和癌症等多种疾病。化疗被认为是癌症患者的黄金治疗方法。然而，化疗是癌症治疗的主要挑战之一。多柔比星（DOX）是一种抗癌药物，可干扰癌细胞的生长和扩散。DOX 可用于治疗各种癌症，包括乳腺癌、神经组织癌、膀胱癌、胃癌、卵巢癌、甲状腺癌、肺癌、骨癌、肌肉癌、关节癌和软组织癌。miRNA 通过调节细胞凋亡过程对化疗耐药性产生调节作用。miRNAs 可影响的主要生物通路包括 PI3K 通路。本综述旨在介绍目前对miRNAs影响细胞凋亡、p53和PTEN/PI3K/Akt信号通路与DOX耐药相关的机制和作用的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Functional & Integrative Genomics 生物-遗传学

CiteScore

3.50

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?