Cytotoxicity of the exhaled aerosol particles from the usage of conventional cigarette and heated tobacco product as determined by a novel “Cells-on-Particles” exposure model in vitro

IF 7.6 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution Pub Date : 2024-08-30 DOI:10.1016/j.envpol.2024.124870

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Abstract

The exposure and health implications of exhaled aerosol particles from tobacco products remain a critical area of concern in public health. This research aimed to characterize the cytotoxicity of exhaled aerosol particles from conventional cigarettes (CC) and heated tobacco products (HTP) using a novel “Cells-on-Particles” integrated aerosol sampling and cytotoxicity in vitro testing platform. The research uniquely captures the physical and chemical characteristics of aerosols by depositing them onto fibrous matrixes, enabling a more accurate representation of exposure conditions. New insights were provided into the differences between CC and HTP in terms of particle size distributions, cell viability, metabolic activity, and the expression of genes related to xenobiotic metabolism and oxidative stress. This approach marks a significant advancement in the field by offering a more direct and representative method to evaluate the potential health hazards of tobacco aerosol particles.

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通过新型 "细胞-颗粒 "体外暴露模型确定使用传统卷烟和加热烟草制品所产生的呼出气溶胶颗粒的细胞毒性。

烟草制品呼出气溶胶粒子的暴露和对健康的影响仍然是公共卫生的一个重要关注领域。这项研究旨在利用一种新型的 "颗粒上的细胞 "体外暴露模型，确定传统香烟（CC）和加热烟草制品（HTP）呼出气溶胶颗粒的细胞毒性特征。这项研究通过将气溶胶沉积在纤维基质上，独特地捕捉到了气溶胶的物理和化学特性，从而更准确地反映了暴露条件。研究人员对 CC 和 HTP 在粒度分布、细胞活力、代谢活性以及与异生物代谢和氧化应激有关的基因表达方面的差异有了新的认识。这种方法为评估烟草气溶胶颗粒对健康的潜在危害提供了一种更直接、更具代表性的方法，标志着该领域的重大进步。

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.

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