Rh(III)-Catalyzed Sequential ortho-C-H Bond Annulation and Desulfonylation of 3-Aryl-2H-benzo[e][1,2,4]thiadiazine-1,1-dioxides: Access to 1-Aminoisoquinolines.

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2024-08-30 DOI:10.1002/asia.202400723

B V Subba Reddy, Chidrawar Ajay, Sridhar Balasubramanian

引用次数: 0

Abstract

An efficient Rh(III)-catalyzed C-H functionalization of 3-aryl-2H-benzo[e][1,2,4]thiadiazine-1,1-dioxides with diaryl and dialkyl alkynes has been developed for the first time to the synthesis of 1-aminoisoquinoline derivatives in a single step. This method involves through the formation of two C-C bonds and one C-N bond followed by desulfonylation to generate a novel series of isoquinolines in good to excellent yields. This is a direct method to produce pharmaceutically more relevant scaffolds with a high functional diversity.

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Rh(III)-Catalyzed Sequential ortho-C-H Bond Annulation and Desulfonylation of 3-Aryl-2H-benzo[e][1,2,4]thiadiazine-1,1-dioxides：获得 1-氨基异喹啉。

研究人员首次开发了一种高效的 Rh(III) 催化 C-H 功能化 3-芳基-2H-苯并[e][1,2,4]噻二嗪-1,1-二氧杂环与二芳基和二烷基炔的方法，从而一步合成 1-氨基异喹啉衍生物。该方法通过形成两个 C-C 键和一个 C-N 键，然后进行脱磺反应，生成了一系列新型异喹啉，收率良好甚至极佳。这是一种直接生产具有高度功能多样性的制药相关支架的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).