Recent Advances and Prospects in β-type Titanium Alloys for Dental Implants Applications.

IF 5.4 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS
João V Calazans Neto, Cícero A S Celles, Catia S A F de Andrade, Conrado R M Afonso, Bruna E Nagay, Valentim A R Barão
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Abstract

Titanium and its alloys, especially Ti-6Al-4V, are widely studied in implantology for their favorable characteristics. However, challenges remain, such as the high modulus of elasticity and concerns about cytotoxicity. To resolve these issues, research focuses on β-type titanium alloys that incorporate elements such as Mo, Nb, Sn, and Ta to improve corrosion resistance and obtain a lower modulus of elasticity compatible with bone. This review comprehensively examines current β titanium alloys, evaluating their mechanical properties, in particular the modulus of elasticity, and corrosion resistance. To this end, a systematic literature search was carried out, where 81 articles were found to evaluate these outcomes. In addition, this review also covers the formation of the alloy, processing methods such as arc melting, and its physical, mechanical, electrochemical, tribological, and biological characteristics. Because β-Ti alloys have a modulus of elasticity closer to that of human bone compared to other metal alloys, they help reduce stress shielding. This is important because the alloy allows for a more even distribution of forces by having a modulus of elasticity more similar to that of bone. In addition, these alloys show good corrosion resistance due to the formation of a noble titanium oxide layer, facilitated by the incorporation of β stabilizers. These alloys also show significant improvements in mechanical strength and hardness. Finally, they also have lower cytotoxicity and bacterial adhesion, depending on the β stabilizer used. However, there are persistent challenges that require detailed research in critical areas, such as optimizing the composition of the alloy to achieve optimal properties in different clinical applications. In addition, it is crucial to study the long-term effects of implants on the human body and to advance the development of cutting-edge manufacturing techniques to guarantee the quality and biocompatibility of implants.

Abstract Image

用于牙科植入物的 β 型钛合金的最新进展和前景。
钛及其合金,尤其是钛-6Al-4V,因其良好的特性在植入学中被广泛研究。然而,高弹性模量和细胞毒性等挑战依然存在。为了解决这些问题,研究重点放在了加入钼、铌、锡和钽等元素的 β 型钛合金上,以提高耐腐蚀性并获得与骨骼兼容的较低弹性模量。本综述全面研究了当前的 β 型钛合金,评估了其机械性能,尤其是弹性模量和耐腐蚀性。为此,我们进行了系统的文献检索,发现有 81 篇文章对这些结果进行了评估。此外,本综述还涉及合金的形成、加工方法(如电弧熔化)及其物理、机械、电化学、摩擦学和生物学特性。与其他金属合金相比,β-钛合金的弹性模量更接近人体骨骼的弹性模量,因此有助于减少应力屏蔽。这一点非常重要,因为这种合金的弹性模量更接近骨骼的弹性模量,可以使力的分布更加均匀。此外,由于形成了高贵的钛氧化层,这些合金还具有良好的耐腐蚀性,而β稳定剂的加入则为其提供了便利。这些合金的机械强度和硬度也有显著提高。最后,它们还具有较低的细胞毒性和细菌粘附性,具体取决于所使用的 β 稳定剂。不过,目前仍存在一些挑战,需要在关键领域进行详细研究,例如优化合金的成分,以在不同的临床应用中获得最佳性能。此外,研究植入物对人体的长期影响以及推动尖端制造技术的发展以保证植入物的质量和生物相容性也至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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