Mouse multi-organ proteome

IF 5.9 3区 农林科学 Q1 VETERINARY SCIENCES
Jorge Ferreira
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引用次数: 0
小鼠多器官蛋白质组
器官的发育和成熟是一个复杂的过程,需要多种分子的动态波动和精确平衡,尤其是在青春期。了解生命过程中各器官的调控机制对于阐明衰老疾病等基本生物学问题尤为重要。发表在《自然-通讯》(Nature Communications)上的一项研究展示了 C57BL/6JN 雄性和雌性小鼠从婴儿期到成年期三个关键发育阶段的多器官蛋白质组图谱。为了研究小鼠器官蛋白质从婴儿期到成年期的动态变化,研究小组对出生后第1、4和8周分离的10个器官(脑、心、肺、肝、肾、脾、胃、肠、肌肉和皮肤)进行了蛋白质组分析。该图谱包含 11,000 种蛋白质,显示了 115 个与年龄相关的蛋白质组,为了解驱动器官发育和成熟的分子机制提供了有用的资源:Wang, Q. et al.Commun.15, 5752 (2024)
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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