Effect of GBA1 Mutations and APOE Polymorphisms on Survival and Progression Among Ashkenazi Jews with Dementia with Lewy Bodies

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2024-08-30 DOI:10.1002/mds.30003

Tamara Shiner MBChB, PhD, Gitit Kavé PhD, Anat Mirelman PhD, Keren Regev MD, Yoav Piura MD, Orly Goldstein PhD, Mali Gana Weisz PhD, Anat Bar-Shira PhD, Tanya Gurevich MD, Avi Orr-Urtreger MD, PhD, Roy N. Alcalay MD, Nir Giladi MD, Noa Bregman MD

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引用次数: 0

Abstract

Background

Glucocerebrosidase 1 (GBA1) mutations are associated with reduced survival in Parkinson's disease but their effect on survival in dementia with Lewy bodies (DLB) is unclear.

Objective

To assess the impact of GBA1 mutations on survival among Ashkenazi Jews with DLB, while controlling for APOE status.

Methods

One hundred and forty participants from Tel Aviv Medical Center, Israel were genotyped for GBA1 mutations and APOE polymorphisms. Survival rates and follow-up cognitive screening scores were analyzed.

Results

GBA1 mutation carriers had a two-fold increased risk of death (HR = 1.999), while APOE status did not independently affect survival. In a subset of patients with available clinical data (N = 63), carriers of the APOE ε4 allele showed faster cognitive deterioration, while GBA1 mutation carriers also declined more rapidly albeit not significantly.

Conclusion

Understanding the genetic effects on survival and progression is crucial for patient counseling and inclusion in clinical trials.

Abstract Image

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GBA1 基因突变和 APOE 多态性对阿什肯纳兹犹太人路易体痴呆症患者的存活率和病情发展的影响

背景葡糖脑 1 (GBA1) 基因突变与帕金森病患者存活率降低有关，但其对路易体痴呆症 (DLB) 患者存活率的影响尚不清楚。结果GBA1基因突变携带者的死亡风险增加了两倍（HR = 1.999），而APOE状态并不独立影响生存。在有临床数据的患者子集中（N = 63），APOE ε4等位基因携带者的认知能力衰退更快，而GBA1突变携带者的认知能力衰退也更快，但不明显。© 2024 The Author(s).运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.