Evaluation of subclinical left ventricular systolic dysfunction in patients with type 2 diabetes mellitus by combining myocardial work and triglyceride-glucose index

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques Pub Date : 2024-08-30 DOI:10.1111/echo.15913

Ting Wu PhD, Lu Chen MS, Yin Li MS, Chunquan Zhang PhD

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引用次数: 0

Abstract

Background and Aim

Type 2 diabetes mellitus (T2DM) frequently presents subclinical left ventricular systolic dysfunction. The TyG index is a surrogate indicator of insulin resistance and is closely related to heart failure (HF). This study aimed to evaluate subclinical systolic dysfunction in T2DM by combining myocardial work (MW) and the TyG index and to investigate the risk factors for MW.

Methods

This study included 102 diabetic patients and 78 healthy control subjects, and the diabetic group was divided into three subgroups based on the TyG index. LV global longitudinal strain (GLS), global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and global myocardial work efficiency (GWE) were measured in all subjects. GLS and MW were compared between the diabetic and control groups and between subgroups. Regression models were applied to analyze the risk factors for MW in diabetic patients.

Results

GLS, GWI, GCW, and GWE significantly increased, and GWW significantly decreased in the diabetic group (all p < .01). GWI and GCW were significantly lower in the T3 subgroup than in the T1 and T2 subgroups (all p < .05). The TyG index, sex (female), BMI, systolic blood pressure (SBP), and total cholesterol (TC) were independent risk factors for GWI and GCW, and HbA1c was an independent risk factor for GWI.

Conclusions

MW accurately revealed subtle changes in subclinical LV systolic dysfunction in T2DM patients. An elevated TyG index was strongly associated with decreased GWI and GCW. The TyG index, sex (female), BMI, SBP, and TC were independent risk factors for GWI and GCW, and HbA1c was an independent risk factor for GWI.

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结合心肌功和甘油三酯-葡萄糖指数评估 2 型糖尿病患者亚临床左心室收缩功能障碍

背景和目的 2型糖尿病（T2DM）经常出现亚临床左心室收缩功能障碍。TyG指数是胰岛素抵抗的替代指标，与心力衰竭（HF）密切相关。本研究旨在通过结合心肌功（MW）和TyG指数评估T2DM亚临床收缩功能障碍，并研究MW的风险因素。方法本研究纳入 102 名糖尿病患者和 78 名健康对照组受试者，根据 TyG 指数将糖尿病组分为三个亚组。测量所有受试者的左心室整体纵向应变（GLS）、整体心肌做功指数（GWI）、整体建设性做功（GCW）、整体浪费做功（GWW）和整体心肌做功效率（GWE）。比较了糖尿病组和对照组之间以及亚组之间的 GLS 和 MW。应用回归模型分析糖尿病患者 MW 的风险因素。结果糖尿病组的 GLS、GWI、GCW 和 GWE 显著增加，GWW 显著减少（所有 p 均为 0.01）。T3 亚组的 GWI 和 GCW 明显低于 T1 和 T2 亚组（所有 p 均为 0.05）。TyG 指数、性别（女性）、体重指数（BMI）、收缩压（SBP）和总胆固醇（TC）是 GWI 和 GCW 的独立危险因素，而 HbA1c 是 GWI 的独立危险因素。结论 MW 能准确揭示 T2DM 患者亚临床左心室收缩功能障碍的细微变化。TyG 指数升高与 GWI 和 GCW 下降密切相关。TyG 指数、性别（女性）、体重指数、SBP 和 TC 是 GWI 和 GCW 的独立危险因素，而 HbA1c 是 GWI 的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques 医学-心血管系统

CiteScore

2.40

自引率

6.70%

发文量

211

审稿时长

3-6 weeks

期刊介绍： Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.