Association between changes in glycosylated hemoglobin during the second and third trimesters and adverse pregnancy outcomes among women without hyperglycemia in pregnancy

IF 6.1 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
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Abstract

Objective

To explore the relationship between changes in glycated hemoglobin (HbA1c) during the second and third trimesters and adverse pregnancy outcomes among women without hyperglycemia in pregnancy (HIP).

Research design and methods: A total of 1,057 pregnant women who underwent serum HbA1c and delivered at Women’s Hospital, Zhejiang University School of Medicine from May 2022 to March 2023, were included in this study. They were divided into four groups. Associations were evaluated using multivariate logistic regression analysis.

Results

In our study, an upward trend in HbA1c levels in the second trimester (HbA1c_S) and third trimester (HbA1c_T) among women without HIP was demonstrated. Multivariate logistics regression analysis showed significant associations: Pregnant women with HbA1c_S<5.5 %, HbA1c_T≥6.1 %, or with HbA1c_S≥5.5 %, HbA1c_T<6.1 % had a significant correlation with hypertensive disorders of pregnancy (HDP) (aOR:2.72, 95 %CI=1.24–5.97;aOR:2.59, 95 %CI=1.15–5.84). Furthermore, for each 1 % increase in the difference value of HbA1c between the second and third trimesters, the risk of HDP increased about 1.96 times, and the risk of delivering a large-for-gestational-age baby increased about 1.30 times.

Conclusion

Among pregnant women without HIP, elevated HbA1c levels in the second or third trimester are associated with increased risks of adverse pregnancy outcomes.

怀孕第二和第三个月期间糖化血红蛋白的变化与妊娠期无高血糖妇女的不良妊娠结局之间的关系
目的 探讨无妊娠期高血糖(HIP)的孕妇第二和第三个孕期糖化血红蛋白(HbA1c)的变化与不良妊娠结局之间的关系:本研究纳入了2022年5月至2023年3月期间在浙江大学医学院附属女子医院接受血清HbA1c检查并分娩的1057名孕妇。她们被分为四组。结果 在我们的研究中,未患 HIP 的产妇在第二孕期(HbA1c_S)和第三孕期(HbA1c_T)的 HbA1c 水平呈上升趋势。多变量物流回归分析显示两者之间存在显著关联:HbA1c_S<5.5 %、HbA1c_T≥6.1 %或 HbA1c_S≥5.5 %、HbA1c_T<6.1 %的孕妇与妊娠高血压疾病(HDP)有显著相关性(aOR:2.72, 95 %CI=1.24-5.97;aOR:2.59, 95 %CI=1.15-5.84)。此外,在第二和第三孕期,HbA1c 的差值每增加 1%,发生 HDP 的风险就会增加约 1.96 倍,而分娩巨大胎儿的风险则会增加约 1.30 倍。
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来源期刊
Diabetes research and clinical practice
Diabetes research and clinical practice 医学-内分泌学与代谢
CiteScore
10.30
自引率
3.90%
发文量
862
审稿时长
32 days
期刊介绍: Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.
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