Neurophysiological markers of disease severity and cognitive dysfunction in major depressive disorder: A TMS-EEG study

IF 5.3 1区心理学 Q1 PSYCHOLOGY, CLINICAL

International Journal of Clinical and Health Psychology Pub Date : 2024-07-01 DOI:10.1016/j.ijchp.2024.100495

Deyang Li , Xingxing Li , Jiaxin Li , Junyao Liu , Ruichenxi Luo , Yanli Li , Dongmei Wang , Dongsheng Zhou , Xiang-Yang Zhang

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Abstract

Background

Transcranial magnetic stimulation-electroencephalography (TMS-EEG) is a powerful technique to study the neuropathology and biomarkers of major depressive disorder (MDD). This study investigated cortical activity and its relationship with clinical symptoms and cognitive dysfunction in MDD patients by indexing TMS-EEG biomarkers in the dorsolateral prefrontal cortex (DLPFC).

Methods

133 patients with MDD and 76 healthy individuals participated in this study. Single-pulse TMS was performed on the left DLPFC to obtain TMS-evoked potential (TEP) indices. TMS-EEG waveforms and components were determined by global mean field amplitude. We used the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to measure participants’ cognitive function.

Results

Patients with MDD had a lower excitatory P180 index compared to healthy controls, and P180 amplitude was negatively correlated with the severity of depressive and anxiety symptoms in patients with MDD. In the MDD group, P30 amplitude was negatively associated with RBANS Visuospatial/ Constructional index and total score.

Conclusions

TMS-EEG findings suggest that abnormal cortical excitation and inhibition induced by TMS on the DLPFC are associated with the severity of clinical symptoms and cognitive dysfunction in patients with MDD. P180 and P30 have the potential to serve as neurophysiological biomarkers of clinical symptoms and cognitive dysfunction in MDD patients, respectively.

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重度抑郁障碍疾病严重程度和认知功能障碍的神经生理学标志物：TMS-EEG 研究

背景经颅磁刺激-脑电图（TMS-EEG）是研究重度抑郁障碍（MDD）的神经病理学和生物标志物的一项强大技术。本研究通过对背外侧前额叶皮层（DLPFC）的 TMS-EEG 生物标记物进行索引，研究了 MDD 患者的皮层活动及其与临床症状和认知功能障碍的关系。对左侧 DLPFC 进行单脉冲 TMS，以获得 TMS 诱发电位（TEP）指数。TMS-EEG 波形和成分是通过全局平均场振幅确定的。结果与健康对照组相比，MDD患者的兴奋性P180指数较低，P180振幅与MDD患者抑郁症状和焦虑症状的严重程度呈负相关。在 MDD 组中，P30 振幅与 RBANS 视空间/构造指数和总分呈负相关。P180 和 P30 有可能分别作为 MDD 患者临床症状和认知功能障碍的神经生理学生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical and Health Psychology PSYCHOLOGY, CLINICAL-

CiteScore

10.70

自引率

5.70%

发文量

审稿时长

33 days

期刊介绍： The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.