Dimethyl sulfoxide-mediated dibromination of gem-difluoroalkenes with hydrobromic acid as reagent

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Fluorine Chemistry Pub Date : 2024-08-25 DOI:10.1016/j.jfluchem.2024.110336

Xiaoying Wang, Jiaxi Cai, Xin Liu, Xin-Hua Duan, Mingyou Hu

引用次数: 0

Abstract

A method for the oxidative dibromination of gem-difluoroalkenes has been devised, employing HBr as the brominating agent and utilizing DMSO as both a mild oxidant and solvent. These uncomplicated conditions provide a high bromide atom economy, coupled with the accessibility and cost-effectiveness of DMSO and HBr. This approach notably expands the scope of gem-difluoroalkenes amenable to dibromination and furnishes a valuable precursor for ¹⁸F radiolabeling applications.

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二甲基亚砜介导的以氢溴酸为试剂的二氟烯烃二溴化反应

采用 HBr 作为溴化剂，并利用二甲基亚砜作为温和的氧化剂和溶剂，设计出了一种氧化二溴化 gem-difluoroalkenes 的方法。这些并不复杂的条件提供了高溴原子经济性，加上二甲基亚砜和 HBr 的易获得性和成本效益。这种方法显著扩大了可进行二溴化反应的二氟烯烃的范围，并为 18F 放射性标记应用提供了一种有价值的前体。

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.