Exploring the healing powers of Saikosaponin A: A review of current perspectives

Abstract

Introduction

Saikosaponin A (SSA), a triterpenoid saponin derived from Radix Bupleuri, is a prominent bioactive compound known for its therapeutic potential. Importantly, SSA is recognized for its widespread use in contemporary Chinese medicinal formulations. The current review highlights SSA's promising role in developing pharmaceuticals and dietary supplements for diverse medical applications, supported by extensive empirical evidence (2001–2024).

Methodology

Literature search across Google Scholar, Scopus, PubMed, and Web of Science, covering publications from 2001 to 2024, aimed to gather extensive information on the pharmacological properties of Saikosaponin A. Using keywords such as “Saikosaponin A,” “Oxidative stress,” “Cancer,” “Inflammation,” “Neuroprotection,” and “Apoptosis,” this review consolidates existing knowledge and offers potential avenues for future research.

Results

This study incorporates findings from various in vitro and in vivo investigations to evaluate SSA's efficacy across multiple health conditions, including cancer, inflammatory diseases, viral infections, cardiac ailments, and neurological disorders. The results demonstrate that SSA exhibits significant therapeutic effects in treating various cancers, mitigating inflammation, providing neuroprotection in conditions such as Parkinson's disease, epilepsy, and depression, combating influenza A virus, and aiding in obesity management.

Discussion

Conclusively, this review highlights the therapeutic potential of SSA, underscoring its importance in treating chronic diseases related to the central nervous system, neoplasms, and inflammatory pathways. Continued research into SSA could yield significant advancements in managing these conditions, reinforcing its value in both traditional and modern medical practices.