Evaluating the effectiveness of transcranial direct current stimulation on improving cognitive function in bipolar patients

Q3 Psychology

Journal of Affective Disorders Reports Pub Date : 2024-07-01 DOI:10.1016/j.jadr.2024.100818

Ali Talaei , Ali Akbari , Mahdiyeh Sarraf-Razavi , Shabnam Niroumand , Dina Ganji , Maryam Aghasizadeh , Ali Azadmand , Maryam Tayyebi-Meybodi , Sanam Tayyebi-Meybodi

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Abstract

Background

Bipolar disorder is classified as one of the most debilitating mental diseases. Although patients receive medical treatment, cognitive deficits remain in the euthymic phase in many patients. It is hypothesized that brain electrical stimulation protocols that increase cognitive function may increase the quality of life. Therefore, this study aimed to evaluate the effectiveness of transcranial direct current stimulation in improving cognitive function in bipolar patients in the euthymic phase.

Methods & Materials

In a double-blind, sham-controlled- clinical trial, 46 euthymic bipolar patients diagnosed based on DSM-V were randomly divided into the two intervention and control groups. tDCS was applied for the intervention group using an anode electrode at the left dorsolateral-peripheral cortex (F3) and the cathode at the right dorsolateral-frontal (F4) (based on the 10/20 system) at 2 mA for 20 min. The Strop Color and Word Test, The Rey Auditory Verbal Learning Test (RAVLT), and The Wechsler Adult Intelligence Scale (WAISR) were evaluated before, at the end of the third and the seventh weeks of the intervention. Statistical analysis was performed using SPSS v 16.

Results

The scores of immediate and delayed auditory memory and visual memory in the intervention group, unlike the control group, improved significantly after treatment. Moreover, Wechsler's working memory score in the intervention group improved significantly after treatment. Consistent and inconsistent answers scores were also significantly improved in the intervention group compared with the controls.

Conclusion

The present study indicated that tDCS might be an efficient and safe method for improving cognitive function in euthymic bipolar patients.

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评估经颅直流电刺激对改善双相情感障碍患者认知功能的效果

背景躁郁症被列为最令人衰弱的精神疾病之一。尽管患者接受了药物治疗，但许多患者在缓解期仍存在认知障碍。据推测，能提高认知功能的脑电刺激方案可提高患者的生活质量。因此，本研究旨在评估经颅直流电刺激在改善躁狂症痊愈期患者认知功能方面的效果。方法与amp; 材料在一项双盲、假对照临床试验中，46名根据DSM-V诊断的躁狂症痊愈期患者被随机分为干预组和对照组。干预组在左侧背外侧-外周皮层（F3）处使用阳极电极，在右侧背外侧-额叶（F4）处使用阴极电极（基于 10/20 系统），电流为 2 mA，持续 20 分钟。在干预前、干预第三周和第七周结束时，分别对 Strop 颜色和单词测试、雷伊听觉言语学习测试（RAVLT）和韦氏成人智力量表（WAISR）进行了评估。结果与对照组不同的是，干预组的即时和延迟听觉记忆及视觉记忆得分在治疗后有显著提高。此外，干预组的韦氏工作记忆得分在治疗后也有明显改善。结论本研究表明，tDCS 可能是一种有效且安全的改善躁狂症患者认知功能的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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