{"title":"Tumor vasculature associated nanomedicine strategies","authors":"","doi":"10.1016/j.ccr.2024.216189","DOIUrl":null,"url":null,"abstract":"<div><p>The tumor vasculature plays a crucial role in promoting tumor growth and metastasis, showcasing heterogeneity in terms of tissue composition, functionality, and structural characteristics. The main limitation of traditional anti-tumor therapy arises from the disordered occlusion and structural abnormalities present within the vascular network of the tumor, which create a bottleneck effect. Hence, the advancement of nanomedicine techniques targeting the tumor vascular system offer a fresh and exciting direction for the treatment of cancer. In this review, the intricate dynamics between the tumor microenvironment (TME) and the tumor vasculature is explored with a focus on the functions of hypoxia, increased angiogenic factor expression, and inflammatory cytokines in the TME. Furthermore, this review provides a comprehensive analysis of various vascular-related treatments, delving into the mechanisms behind each approach. Specifically, the recent advancements in nanomedicines targeting for therapeutic strategies are highlighted, namely anti-tumor angiogenic therapy, tumor vascular structure disruption, tumor vasculature normalization, and embolization therapy. Lastly, an overview of the challenges and prospects associated with tumor vascular therapy using nanomedicines is presented.</p></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":null,"pages":null},"PeriodicalIF":20.3000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010854524005356","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
The tumor vasculature plays a crucial role in promoting tumor growth and metastasis, showcasing heterogeneity in terms of tissue composition, functionality, and structural characteristics. The main limitation of traditional anti-tumor therapy arises from the disordered occlusion and structural abnormalities present within the vascular network of the tumor, which create a bottleneck effect. Hence, the advancement of nanomedicine techniques targeting the tumor vascular system offer a fresh and exciting direction for the treatment of cancer. In this review, the intricate dynamics between the tumor microenvironment (TME) and the tumor vasculature is explored with a focus on the functions of hypoxia, increased angiogenic factor expression, and inflammatory cytokines in the TME. Furthermore, this review provides a comprehensive analysis of various vascular-related treatments, delving into the mechanisms behind each approach. Specifically, the recent advancements in nanomedicines targeting for therapeutic strategies are highlighted, namely anti-tumor angiogenic therapy, tumor vascular structure disruption, tumor vasculature normalization, and embolization therapy. Lastly, an overview of the challenges and prospects associated with tumor vascular therapy using nanomedicines is presented.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.