Effects of elevated intraocular pressure on alpha ganglion cells in experimental glaucoma mice

IF 1.5 4区心理学 Q4 NEUROSCIENCES

Vision Research Pub Date : 2024-08-31 DOI:10.1016/j.visres.2024.108475

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引用次数: 0

Abstract

Glaucoma is a leading cause of blindness worldwide and glaucoma patients exhibit an early diffuse loss of retinal sensitivity followed by focal loss of RGCs. Combining some previous published results and some new data, this paper provides our current view on how high IOP (H-IOP) affects the light response sensitivity of a subset of RGCs, the alpha-ganglion cells (αGCs), as well as their presynaptic bipolar cells (DBCs and HBCs) and A2 amacrine cells (AIIACs) in dark-adapted mouse retinas. Our data demonstrate that H-IOP in experimental glaucoma mice significantly decreases light-evoked spike response sensitivity of sONαGCs and sOFFαGCs (i.e., raises thresholds by 1.5–2.5 log units), but not that of the tONαGCs and tOFFαGCs. The sensitivity loss in sONαGCs and sOFFαGCs is mediated by a H-IOP induced suppression of AIIAC response which is caused by a decrease of transmission efficacy of the DBC_R→AIIAC synapse. We also provide evidence supporting the hypothesis that BK channels in the A17AC→DBC_R feedback synapse are the H-IOP sensor that regulates the DBC_R→AIIAC synaptic efficacy, as BK channel blocker IBTX mimics the action of H-IOP. Our results provide useful information for designing strategies for early detection and possible treatments of glaucoma as physiological changes occur before irreversible structural damage.

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眼压升高对实验性青光眼小鼠α神经节细胞的影响

青光眼是导致全球失明的主要原因之一，青光眼患者早期会出现弥漫性视网膜灵敏度下降，随后会出现局灶性 RGC 损失。结合之前发表的一些结果和一些新数据，本文就高眼压（H-IOP）如何影响暗适应小鼠视网膜中的RGCs亚群--α-神经节细胞（αGCs）及其突触前双极细胞（DBCs和HBCs）和A2羊膜细胞（AIIACs）的光反应灵敏度提出了我们目前的看法。我们的数据表明，实验性青光眼小鼠的高眼压会显著降低 sONαGCs 和 sOFFαGCs 的光诱发尖峰反应灵敏度（即阈值升高 1.5-2.5 对数单位），但不会降低 tONαGCs 和 tOFFαGCs 的灵敏度。sONαGCs和sOFFαGCs的敏感性下降是由H-IOP诱导的AIIAC反应抑制介导的，而AIIAC反应抑制是由DBCR→AIIAC突触的传导效率下降引起的。我们还提供了支持以下假设的证据：A17AC→DBCR反馈突触中的BK通道是调节DBCR→AIIAC突触功效的H-IOP传感器，因为BK通道阻断剂IBTX能模拟H-IOP的作用。我们的研究结果为设计青光眼早期检测和可能的治疗策略提供了有用的信息，因为生理变化发生在不可逆转的结构损伤之前。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vision Research 医学-神经科学

CiteScore

3.70

自引率

16.70%

发文量

111

审稿时长

66 days

期刊介绍： Vision Research is a journal devoted to the functional aspects of human, vertebrate and invertebrate vision and publishes experimental and observational studies, reviews, and theoretical and computational analyses. Vision Research also publishes clinical studies relevant to normal visual function and basic research relevant to visual dysfunction or its clinical investigation. Functional aspects of vision is interpreted broadly, ranging from molecular and cellular function to perception and behavior. Detailed descriptions are encouraged but enough introductory background should be included for non-specialists. Theoretical and computational papers should give a sense of order to the facts or point to new verifiable observations. Papers dealing with questions in the history of vision science should stress the development of ideas in the field.

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