Computational strategies in Klebsiella pneumoniae vaccine design: navigating the landscape of in silico insights.

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Bruno Douradinha
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Abstract

The emergence of multidrug-resistant Klebsiella pneumoniae poses a grave threat to global public health, necessitating urgent strategies for vaccine development. In this context, computational tools have emerged as indispensable assets, offering unprecedented insights into klebsiellal biology and facilitating the design of effective vaccines. Here, a review of the application of computational methods in the development of K. pneumoniae vaccines is presented, elucidating the transformative impact of in silico approaches. Through a systematic exploration of bioinformatics, structural biology, and immunoinformatics techniques, the complex landscape of K. pneumoniae pathogenesis and antigenicity was unravelled. Key insights into virulence factors, antigen discovery, and immune response mechanisms are discussed, highlighting the pivotal role of computational tools in accelerating vaccine development efforts. Advancements in epitope prediction, antigen selection, and vaccine design optimisation are examined, highlighting the potential of in silico approaches to update vaccine development pipelines. Furthermore, challenges and future directions in leveraging computational tools to combat K. pneumoniae are discussed, emphasizing the importance of multidisciplinary collaboration and data integration. This review provides a comprehensive overview of the current state of computational contributions to K. pneumoniae vaccine development, offering insights into innovative strategies for addressing this urgent global health challenge.

肺炎克雷伯氏菌疫苗设计中的计算策略:浏览硅学洞察的全貌。
耐多药肺炎克雷伯氏菌的出现对全球公共卫生构成了严重威胁,因此需要制定紧急疫苗开发战略。在这种情况下,计算工具已成为不可或缺的资产,它提供了前所未有的克雷伯氏菌生物学洞察力,并促进了有效疫苗的设计。本文回顾了计算方法在肺炎克雷伯菌疫苗研发中的应用,阐明了硅学方法的变革性影响。通过对生物信息学、结构生物学和免疫信息学技术的系统探索,揭开了肺炎克雷伯菌发病机制和抗原性的复杂面貌。文章讨论了对毒力因子、抗原发现和免疫反应机制的重要见解,强调了计算工具在加速疫苗开发工作中的关键作用。研究还探讨了表位预测、抗原选择和疫苗设计优化方面的进展,强调了硅学方法在更新疫苗开发流程方面的潜力。此外,还讨论了利用计算工具防治肺炎克氏菌所面临的挑战和未来发展方向,强调了多学科合作和数据整合的重要性。这篇综述全面概述了计算对肺炎克雷伯菌疫苗开发的贡献现状,为应对这一紧迫的全球健康挑战提供了创新战略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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