Prevalence and characteristics of dysfunctional breathing in patients with asthma in the Japanese population

IF 2.4 Q2 RESPIRATORY SYSTEM
Natsuki Takeda , Toshiyuki Koya , Takashi Hasegawa , Moe Tanaka , Takahiro Matsuda , Yui Murai , Shun Naramoto , Yosuke Kimura , Kenjiro Shima , Makoto Kurokawa , Ami Aoki , Chieko Yoshida , Takuro Sakagami , Shuichiro Maruoka , Yasuhiro Gon , Toshiaki Kikuchi , the Niigata Asthma Treatment Study Group
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引用次数: 0

Abstract

Background

Dysfunctional breathing (DB) is a major asthma comorbidity; however, it is not well recognized in Japan. Moreover, it has rarely been reported in the asthma population, and its clinical characteristics are unclear. We aimed to clarify the clinical characteristics of DB as a comorbidity in patients with asthma in Japan. Questionnaire surveys were conducted among patients with asthma at medical facilities in three regions of Japan (Niigata, Kumamoto, and Tokyo).

Methods

This cross-sectional questionnaire survey targeting patients with asthma who had regularly visited medical institutions and their doctors was conducted from September to November 2021. The questionnaire addressed the control status and method of treatment. The diagnosis of DB was evaluated using the Nijmegen questionnaire (NQ).

Results

There were 2087 eligible participants. Based on their NQ scores, 217 patients were classified into the DB group (NQ ≥ 19). There were significant differences with respect to sex, disease duration, Asthma Control Test (ACT) scores, Patient Health Questionnaire-9 (PHQ-9) scores, type-2 biomarkers, pulmonary function indices, treatment methods, severity, and asthma exacerbations in the previous year between the DB and non-DB groups. In the multivariate analysis, there were significant differences in sex, disease duration (≥15 y), ACT scores (<20), and PHQ-9 scores (≥10). The cluster analysis of cases with DB classified the population into four clusters.

Conclusions

The asthma population with DB exhibited several characteristics, including depression and poorly controlled asthma. Further large-scale interventional investigations with longer follow-up periods are necessary to verify these findings.

日本人口中哮喘患者呼吸功能紊乱的发生率和特征
背景功能性呼吸障碍(DB)是一种主要的哮喘合并症,但在日本尚未得到充分认识。此外,在哮喘人群中也鲜有报道,其临床特征也不明确。我们旨在明确 DB 作为日本哮喘患者合并症的临床特征。我们在日本三个地区(新泻、熊本和东京)的医疗机构对哮喘患者进行了问卷调查。方法这项横断面问卷调查于 2021 年 9 月至 11 月进行,调查对象为定期到医疗机构就诊的哮喘患者及其医生。调查问卷涉及控制状况和治疗方法。结果共有 2087 名符合条件的参与者。根据 NQ 评分,217 名患者被归入 DB 组(NQ ≥ 19)。DB组和非DB组在性别、病程、哮喘控制测试(ACT)得分、患者健康问卷-9(PHQ-9)得分、2型生物标志物、肺功能指数、治疗方法、严重程度以及前一年的哮喘恶化情况等方面存在明显差异。在多变量分析中,性别、病程(≥15 年)、ACT 评分(<20)和 PHQ-9 评分(≥10)存在显著差异。结论患有DB的哮喘患者有几个特点,包括抑郁和哮喘控制不佳。要验证这些研究结果,有必要进一步进行大规模的干预性调查,并延长随访时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Respiratory investigation
Respiratory investigation RESPIRATORY SYSTEM-
CiteScore
4.90
自引率
6.50%
发文量
114
审稿时长
64 days
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